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Roles of the cyclin dependent kinase...

Jovanovic, Aleksandra.

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Roles of the cyclin dependent kinase inhibitorsp21 andp27 in gastrointestinal tract homeostasis.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Roles of the cyclin dependent kinase inhibitorsp21 andp27 in gastrointestinal tract homeostasis./
作者:	Jovanovic, Aleksandra.
面頁冊數:	131 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1154.
Contained By:	Dissertation Abstracts International65-03B.
標題:	Biology, Molecular. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3126822
ISBN:	0496741007

Roles of the cyclin dependent kinase inhibitorsp21 andp27 in gastrointestinal tract homeostasis.
Jovanovic, Aleksandra.

Roles of the cyclin dependent kinase inhibitorsp21 andp27 in gastrointestinal tract homeostasis. - 131 p.

Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1154.

Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2004.

The cyclin-dependent kinase inhibitors p21 and p27 are multifunctional proteins that play roles in cell cycle inhibition and proliferation, cell differentiation, senescence and apoptosis. We investigate the role of p21 and p27 in the mouse gastrointestinal tract using mouse knockout models.

ISBN: 0496741007Subjects--Topical Terms:

1017719
Biology, Molecular.

Roles of the cyclin dependent kinase inhibitorsp21 andp27 in gastrointestinal tract homeostasis.
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245 1 0 $a Roles of the cyclin dependent kinase inhibitorsp21 andp27 in gastrointestinal tract homeostasis.
300 $a 131 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1154.
500 $a Chairperson: Angela L. Tyner.
502 $a Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2004.
520 $a The cyclin-dependent kinase inhibitors p21 and p27 are multifunctional proteins that play roles in cell cycle inhibition and proliferation, cell differentiation, senescence and apoptosis. We investigate the role of p21 and p27 in the mouse gastrointestinal tract using mouse knockout models.
520 $a Intestinal epithelium undergoes rapid and continuous renewal throughout life. We found that p21 and p27 are not essential factors for the progression of proliferation in mouse intestine, but act as inhibitors of proliferation. Also, we showed that p21 and p27 are not essential for differentiation of intestinal epithelial cells, but might play a role in regulating the abundance of goblet and Paneth cells. In the colon, p21 plays a tumor suppressor function following colon carcinogen treatment.
520 $a Adult hepatocytes are quiescent and rarely divide under normal conditions. We showed that p27 is expressed throughout the liver and is partially responsible for maintaining quiescence in liver. p21 was not detected in wild-type liver, but was induced in liver and other mature tissues of p27-deficient mice.
520 $a Liver injury and repair were examined following carbon tetrachloride (CCl4) administration. p21 plays distinct and opposing roles regulating hepatocyte survival during injury and subsequent repair. Early induction of p21 after CCl4 treatment contributes to necrotic injury whereas later expression leads to the cessation of proliferation and hepatocyte survival. p21-deficient mice had the least injury and the highest levels of hepatic proliferation. Increased replication in p21-deficient livers was counteracted by an increase in hepatocyte apoptosis as detected by caspase-3 activation.
520 $a We investigated the Fas-agonist antibody (Jo2) induced apoptosis in liver. p21-deficient mice showed significant resistance to Jo2 induced hepatic death and a decrease in caspase 3 activity. Bid, a proapoptotic member of Bcl-2 family of proteins was decreased in p21-deficient hepatocytes. The effect of p21 on Bid is probably one of the mechanisms of the proapoptotic actions of p21 in hepatocytes. The knowledge of links between the cell cycle and apoptosis help us understand pathological conditions and identify better therapeutic strategies.
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791 $a Ph.D.
792 $a 2004
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