語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Innate immunity adaptation and sensi...
~
Jacinto, Randolph Bambao.
FindBook
Google Book
Amazon
博客來
Innate immunity adaptation and sensitization by toll-like receptor (TLR)2-, TLR4- and TLR9-specific microbial pathogens in human monocytic cells.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Innate immunity adaptation and sensitization by toll-like receptor (TLR)2-, TLR4- and TLR9-specific microbial pathogens in human monocytic cells./
作者:
Jacinto, Randolph Bambao.
面頁冊數:
169 p.
附註:
Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0644.
Contained By:
Dissertation Abstracts International65-02B.
標題:
Health Sciences, Immunology. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3123673
ISBN:
0496709843
Innate immunity adaptation and sensitization by toll-like receptor (TLR)2-, TLR4- and TLR9-specific microbial pathogens in human monocytic cells.
Jacinto, Randolph Bambao.
Innate immunity adaptation and sensitization by toll-like receptor (TLR)2-, TLR4- and TLR9-specific microbial pathogens in human monocytic cells.
- 169 p.
Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0644.
Thesis (Ph.D.)--Wake Forest University, The Bowman Gray School of Medicine, 2004.
Sepsis with endotoxic shock is the number one cause of death in critical care units in the Unites States. During infection from gram-negative bacteria, lipopolysaccharide (LPS) induces proinflammatory gene expression. Subsequent exposure to LPS, a TLR4 specific microbial agonist, induces a gene specific adaptive cellular response called endotoxin tolerance, a phenomenon common to sepsis whereby expression of proinflammatory mediators are repressed. In light of the growing number of septic cases being attributed to other microbial pathogens, questions regarding the potential of other microbial pathogens to induce similar states of innate immunity adaptation have been raised. This thesis will demonstrate prior exposure to lipoteichoic acid (LTA), a TLR2 specific microbial agonist, induces only homotolerance, a phenomenon whereby repressed innate immune response results from restimulation with the same microbial agonist. Additionally, this thesis will demonstrate that TLR4 can engage in cross-talk with TLR2 and TLR9, inducing both homo- and heterotolerance, a phenomenon whereby repression of the innate immunity results from restimulation with a different microbial agonist.
ISBN: 0496709843Subjects--Topical Terms:
1017716
Health Sciences, Immunology.
Innate immunity adaptation and sensitization by toll-like receptor (TLR)2-, TLR4- and TLR9-specific microbial pathogens in human monocytic cells.
LDR
:03429nmm 2200325 4500
001
1839848
005
20050714101045.5
008
130614s2004 eng d
020
$a
0496709843
035
$a
(UnM)AAI3123673
035
$a
AAI3123673
040
$a
UnM
$c
UnM
100
1
$a
Jacinto, Randolph Bambao.
$3
1928214
245
1 0
$a
Innate immunity adaptation and sensitization by toll-like receptor (TLR)2-, TLR4- and TLR9-specific microbial pathogens in human monocytic cells.
300
$a
169 p.
500
$a
Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0644.
500
$a
Advisers: Charles E. McCall; Liwu Li.
502
$a
Thesis (Ph.D.)--Wake Forest University, The Bowman Gray School of Medicine, 2004.
520
$a
Sepsis with endotoxic shock is the number one cause of death in critical care units in the Unites States. During infection from gram-negative bacteria, lipopolysaccharide (LPS) induces proinflammatory gene expression. Subsequent exposure to LPS, a TLR4 specific microbial agonist, induces a gene specific adaptive cellular response called endotoxin tolerance, a phenomenon common to sepsis whereby expression of proinflammatory mediators are repressed. In light of the growing number of septic cases being attributed to other microbial pathogens, questions regarding the potential of other microbial pathogens to induce similar states of innate immunity adaptation have been raised. This thesis will demonstrate prior exposure to lipoteichoic acid (LTA), a TLR2 specific microbial agonist, induces only homotolerance, a phenomenon whereby repressed innate immune response results from restimulation with the same microbial agonist. Additionally, this thesis will demonstrate that TLR4 can engage in cross-talk with TLR2 and TLR9, inducing both homo- and heterotolerance, a phenomenon whereby repression of the innate immunity results from restimulation with a different microbial agonist.
520
$a
Dissimilar to the adapted phenotype, the innate immunity also exhibits a sensitized phenotype whereby subsequent exposure to LPS enhances proinflammatory gene expression. This thesis will demonstrate that, in contrast to TLR4 and TLR2, CpG ODN, a TLR9 specific microbial agonist induces both states of homo- and heterosensitization to CpG ODN and LPS restimulation, respectively.
520
$a
To determine the molecular mechanisms responsible for the differential expression of innate immunity adaptation and sensitization, investigations into the regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) were made using the THP-1 cell lines as a model for sepsis. Kinase inactivation and protein degradation of IRAK-1 corresponds with LPS homo- and heterotolerance while only kinase inactivation corresponds with LTA homotolerance. With respect to the primed phenotype, IRAK-1 remains responsive in CpG ODN heterosenitization while no kinase activation and degradation were observed in CpG ODN homosensitization. Therefore, distinct alterations in IRAK-1 play a role, at least in part to the induction of innate immunity adaptation and sensitization.
590
$a
School code: 0249.
650
4
$a
Health Sciences, Immunology.
$3
1017716
650
4
$a
Health Sciences, Medicine and Surgery.
$3
1017756
650
4
$a
Biology, Cell.
$3
1017686
690
$a
0982
690
$a
0564
690
$a
0379
710
2 0
$a
Wake Forest University, The Bowman Gray School of Medicine.
$3
1251076
773
0
$t
Dissertation Abstracts International
$g
65-02B.
790
1 0
$a
McCall, Charles E.,
$e
advisor
790
1 0
$a
Li, Liwu,
$e
advisor
790
$a
0249
791
$a
Ph.D.
792
$a
2004
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3123673
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9189362
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入