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Human immunodeficiency virus type 1 ...

Dorman, Karin Saskia.

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Human immunodeficiency virus type 1 genome variability: Recombination and emergence of resistance.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Human immunodeficiency virus type 1 genome variability: Recombination and emergence of resistance./
作者:	Dorman, Karin Saskia.
面頁冊數:	144 p.
附註:	Source: Dissertation Abstracts International, Volume: 62-09, Section: B, page: 4037.
Contained By:	Dissertation Abstracts International62-09B.
標題:	Mathematics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3026304
ISBN:	0493384456

Human immunodeficiency virus type 1 genome variability: Recombination and emergence of resistance.
Dorman, Karin Saskia.

Human immunodeficiency virus type 1 genome variability: Recombination and emergence of resistance. - 144 p.

Source: Dissertation Abstracts International, Volume: 62-09, Section: B, page: 4037.

Thesis (Ph.D.)--University of California, Los Angeles, 2001.

Motivated by the tremendous variability of the Human Immunodeficiency Virus-type 1 (HIV-1) and the need to quantitate and measure the impact of this variability, we build a multisample bootstrap estimate of the p-value for recombination, a deterministic model of the impact of antiretroviral therapy interruptions, and a branching process model of the emergence of drug resistance.

ISBN: 0493384456Subjects--Topical Terms:

515831
Mathematics.

Human immunodeficiency virus type 1 genome variability: Recombination and emergence of resistance.
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245 1 0 $a Human immunodeficiency virus type 1 genome variability: Recombination and emergence of resistance.
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500 $a Source: Dissertation Abstracts International, Volume: 62-09, Section: B, page: 4037.
500 $a Chair: Janet S. Sinsheimer.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2001.
520 $a Motivated by the tremendous variability of the Human Immunodeficiency Virus-type 1 (HIV-1) and the need to quantitate and measure the impact of this variability, we build a multisample bootstrap estimate of the p-value for recombination, a deterministic model of the impact of antiretroviral therapy interruptions, and a branching process model of the emergence of drug resistance.
520 $a Recombinant HIV-1 genomes derive from two distinct HIV-1 parent genomes. The recombinant process is a powerful diversifying force that has been documented in numerous HIV-1 sequences. Accurate identification and confirmation of recombination is important for understanding its impact. Evidence of recombination is often confirmed by calculating the bootstrap support for multiple phylogenies. We develop an estimate of the p-value for recombination that is both more accurate and easier to interpret.
520 $a Structured treatment interruptions are proposed as an alternative approach to treatment for HIV-1 infected individuals. We study the properties of a deterministic model of HIV-1 population dynamics during treatment interruptions. We conclude that the risk of ultimately developing resistance may rise as many as several thousand times with each treatment interruption.
520 $a Building on the known properties of stochastic branching processes, we develop additional results for a continuous time branching process model with immigration. In particular, we derive expressions for the mean, variance, and extinction probabilities of a process with exponentially varying independent Poisson immigration. We apply the results to a model of HIV-1 population dynamics during antiviral therapy to better understand how drug-resistant HIV-1 strains emerge and to fill the gap left by the previous deterministic model, namely "How does low-level resistance first emerge?" While the data necessary to make specific predictions are lacking, we develop the tools that may some day help develop strategies to delay resistance.
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650 4 $a Biology, Biostatistics. $3 1018416
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