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Chaos and complexity in cancer.

Al-Timimi, Ali M.

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Chaos and complexity in cancer.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Chaos and complexity in cancer./
作者:	Al-Timimi, Ali M.
面頁冊數:	116 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5253.
Contained By:	Dissertation Abstracts International65-10B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3151143
ISBN:	0496106686

Chaos and complexity in cancer.
Al-Timimi, Ali M.

Chaos and complexity in cancer. - 116 p.

Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5253.

Thesis (Ph.D.)--George Mason University, 2005.

It is now widely accepted that cancer is essentially a genetic disease likely caused by, or associated with, aberrant gene expression. Unlike simple genetic diseases where an inherited mutation in a single gene is sufficient to determine the pathological phenotype, cancer, among pathogenetic diseases, has the most intricate mechanism where typically numerous mutations are present. Moreover, it is understood that cancer is not a single disease but rather a group of heterogeneous diseases that share common biological properties.

ISBN: 0496106686Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Chaos and complexity in cancer.
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245 1 0 $a Chaos and complexity in cancer.
300 $a 116 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5253.
500 $a Director: D. Curtis Jamison.
502 $a Thesis (Ph.D.)--George Mason University, 2005.
520 $a It is now widely accepted that cancer is essentially a genetic disease likely caused by, or associated with, aberrant gene expression. Unlike simple genetic diseases where an inherited mutation in a single gene is sufficient to determine the pathological phenotype, cancer, among pathogenetic diseases, has the most intricate mechanism where typically numerous mutations are present. Moreover, it is understood that cancer is not a single disease but rather a group of heterogeneous diseases that share common biological properties.
520 $a Current medical theory views the pathology of cancer as an example of a complex adaptive system whose behavior expresses the interplay between order and chaos. With some cancers, tumorigenesis is driven by chaotic behavior, while other cancers show more order in their formation. Accompanying the transformation from normal to neoplastic tissue is an overall decrease in the complexity of the cell.
520 $a We have empirically investigated these notions of chaos and complexity via a study of gene expression in a wide range of normal and cancerous tissues. Our results are in fundamental agreement with what is proposed in the literature.
520 $a The significance of this type of research has been best stated as follows, "Nonlinear dynamic considerations present a new intellectual approach to cancer, which may in addition result in the development of novel therapeutic and diagnostic concepts (Sedivy 1999)."
590 $a School code: 0883.
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