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Human papillomavirus infection and o...

Pintos Vega, Luis Javier.

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Human papillomavirus infection and oral cancer: A case-control study.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Human papillomavirus infection and oral cancer: A case-control study./
作者:	Pintos Vega, Luis Javier.
面頁冊數:	198 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0638.
Contained By:	Dissertation Abstracts International65-02B.
標題:	Health Sciences, Dentistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ88556
ISBN:	0612885569

Human papillomavirus infection and oral cancer: A case-control study.
Pintos Vega, Luis Javier.

Human papillomavirus infection and oral cancer: A case-control study. - 198 p.

Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0638.

Thesis (Ph.D.)--McGill University (Canada), 2003.

Introduction. Human papillomavirus (HPV) has been detected with varying frequency in oral cancers and in normal oral tissues. The main objective of the present study was to examine the association between HPV infection and risk of developing oral cancer.

ISBN: 0612885569Subjects--Topical Terms:

1019378
Health Sciences, Dentistry.

Human papillomavirus infection and oral cancer: A case-control study.
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245 1 0 $a Human papillomavirus infection and oral cancer: A case-control study.
300 $a 198 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0638.
500 $a Adviser: Eduardo L. Franco.
502 $a Thesis (Ph.D.)--McGill University (Canada), 2003.
520 $a Introduction. Human papillomavirus (HPV) has been detected with varying frequency in oral cancers and in normal oral tissues. The main objective of the present study was to examine the association between HPV infection and risk of developing oral cancer.
520 $a Methodology. This investigation, as a component of an international multi-centre study coordinated by the IARC, followed a hospital-based case-control design. Cases consisted of newly diagnosed patients with primary squamous cell carcinoma of the oral cavity, including mouth and oropharynx. Controls were frequency matched to cases by sex, age, and hospital. All subjects were interviewed to elicit detail information on known and putative risk factors.
520 $a Oral exfoliated cells were collected from all subjects for detection of HPV DNA using the PGMY09/11 PCR protocol. Antibodies against HPV 16, 18, and 31 capsids were detected in patients' plasma using an immunoassay technique. Logistic regression was used for estimation of odds ratios (ORs) and 95% confidence intervals (CI) of oral cancer for HPV and other candidate risk factors.
520 $a Results. A total of 72 cases and 129 controls were recruited. HPV DNA was detected in 19% of cases (14 out of 72), and in 5% of controls (6 out of 129). Analysis for cancers related to Waldeyer's ring (palatine tonsil and base of tongue) showed that the OR of disease for detection of high risk HPV types was 19.32 (95%CI:2.3--159.5), after adjustment for socio-demographic characteristics, tobacco and alcohol consumption. The adjusted OR of disease for HPV 16 seropositivity was 31.51 (95%CI:4.5--219.7). Analysis for non tonsillar oral cancers showed that the OR for detection of high risk HPV DNA in oral cells and for seropositivity were 2.14 (95%CI:0.4--13.0) and 3.16 (95%CI:0.8--13.0), respectively.
520 $a Discussion. The results from this study provide evidence supporting a strong association between HPV infection and cancers of the oropharynx, especially those arising from Waldeyer's ring. On the other hand, the association with non tonsillar oral cancers was of much lower magnitude. The biological evidence establishing a firm etiologic link remains to be established for the latter subsites, whereas the association between HPV and Waldeyer's ring carcinomas is consistent with a causal link.
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710 2 0 $a McGill University (Canada). $3 1018122
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