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Quantitative modeling of muscle cont...

Gelfand, Volodymyr.

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Quantitative modeling of muscle contraction.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Quantitative modeling of muscle contraction./
作者:	Gelfand, Volodymyr.
面頁冊數:	178 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-01, Section: B, page: 0107.
Contained By:	Dissertation Abstracts International64-01B.
標題:	Biophysics, General. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3078625
ISBN:	0493995021

Quantitative modeling of muscle contraction.
Gelfand, Volodymyr.

Quantitative modeling of muscle contraction. - 178 p.

Source: Dissertation Abstracts International, Volume: 64-01, Section: B, page: 0107.

Thesis (Ph.D.)--Princeton University, 2003.

The past several centuries of the human history have been marked with a tremendous technical progress. Complicated mechanisms were invented that allowed us to travel and facilitated our everyday life. Yet, how well do we know the natural motor systems that reside inside ourselves? Biophysics of muscle has been improving our understanding since the 1950s. The studies of muscle have brought us the information about how the muscle cells are organized, which proteins populate the muscle filaments, and the large-scale picture of what happens when muscle contracts. But the most fundamental questions are encountered only once we plunge deep into the living matter. Which elements of muscle are responsible for generating the force that is necessary for muscle contraction? What processes on the molecular level lead to the force being generated? Despite the battery of information from X-ray, fluorescence, mechanical and other experiments, all we have so far is a number of competing theories, neither of which has received compelling proof. These theories disagree with each other over multiple concepts, including the roles of specific proteins in the process of force generation. Among these theories there is the crossbridge theory, developed more than 30 years ago, and also there is a significantly younger actin powerstroke theory, which was developed with the direct participation of my scientific advisor, Professor Schutt.

ISBN: 0493995021Subjects--Topical Terms:

1019105
Biophysics, General.

Quantitative modeling of muscle contraction.
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245 1 0 $a Quantitative modeling of muscle contraction.
300 $a 178 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-01, Section: B, page: 0107.
500 $a Adviser: Clarence E. Schutt.
502 $a Thesis (Ph.D.)--Princeton University, 2003.
520 $a The past several centuries of the human history have been marked with a tremendous technical progress. Complicated mechanisms were invented that allowed us to travel and facilitated our everyday life. Yet, how well do we know the natural motor systems that reside inside ourselves? Biophysics of muscle has been improving our understanding since the 1950s. The studies of muscle have brought us the information about how the muscle cells are organized, which proteins populate the muscle filaments, and the large-scale picture of what happens when muscle contracts. But the most fundamental questions are encountered only once we plunge deep into the living matter. Which elements of muscle are responsible for generating the force that is necessary for muscle contraction? What processes on the molecular level lead to the force being generated? Despite the battery of information from X-ray, fluorescence, mechanical and other experiments, all we have so far is a number of competing theories, neither of which has received compelling proof. These theories disagree with each other over multiple concepts, including the roles of specific proteins in the process of force generation. Among these theories there is the crossbridge theory, developed more than 30 years ago, and also there is a significantly younger actin powerstroke theory, which was developed with the direct participation of my scientific advisor, Professor Schutt.
520 $a No theoretical description of a system can be accepted as a valid theory unless it accounts for experimental observations. However, the specific experimental data sufficient to distinguish between plausible theories of muscle contraction has been lacking until recently. The emergence of the time-resolved X-ray data on muscle during quick release allows us to find the missing link necessary for reassessment of the theories of muscle.
520 $a In this thesis, structural processes on two different levels of muscle will be modeled quantitatively on the basis of the actin powerstroke theory. Specific experimental information, obtained elsewhere, will be used for developing the mathematical models of microscopic processes that give rise to muscle contraction. I hope my effort will improve our understanding of how muscles work.
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