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Aging and physical activity: Implica...

Smith, Taro Patrick.

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Aging and physical activity: Implications for human immune function and health.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Aging and physical activity: Implications for human immune function and health./
Author:	Smith, Taro Patrick.
Description:	141 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0647.
Contained By:	Dissertation Abstracts International65-02B.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3123291
ISBN:	0496706024

Aging and physical activity: Implications for human immune function and health.
Smith, Taro Patrick.

Aging and physical activity: Implications for human immune function and health. - 141 p.

Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0647.

Thesis (Ph.D.)--University of Colorado at Boulder, 2004.

The failing of the immune system in aging is characterized by a progressive decline in the antibody and T-cell mediated responses with a concurrent increase in inflammation. The chronically ill population suffers from a myriad of problems, including decreased endurance, mental health, activities of daily living, and balance. Maintaining a physically active lifestyle may mitigate these deficits. The purpose of this dissertation was to examine the role of physical activity on immune function and health status in older adults. Experiment 1 examined the influence of aging and physical activity on primary antibody and T-cell mediated immune responses by challenging subjects with the T-cell dependent protein keyhole-limpet hemocyanin (KLH). The results were that aging significantly reduced all anti-KLH measures except anti-KLH IgG2. Physically active older subjects had significantly improved anti-KLH IgM, IgG, IgG1, and DTH responses, but not IgG2, compared to sedentary older subjects. Experiment 2 tested if physical activity can influence heat shock proteins and inflammation in the aged. The results were that physically active groups had significantly elevated levels of HSP70 and significantly reduced levels of CRP. No significant differences were found in other markers of inflammation. Experiment 3 examined immune responses to KLH, as well as circulating inflammatory markers, in coronary artery disease (CAD) patients. Healthy older adults had a more robust anti-KLH IgM, IgG1 and DTH response than age-matched subjects with CAD. There were no differences in anti-KLH IgG, and IgG2 or in CRP, TNF-alpha, IL-6, IL-10, and cortisol. Experiment 4 applied these exercise principles to chronically ill patients. The physiological, health, and cost benefits of a comprehensive rehabilitation program were examined in medically complex patients. Physical functioning and mental health were assessed by the SF-36, and a medical event questionnaire was collected at baseline and after three months of the program. Strength measures improved by &sim;30% and aerobic power improved by &sim;25% over the three-month period. There were significant improvements in the SF-36 and significant reductions in fall rate, physician visits, and hospitalizations. Conclusion. Taken together, these findings support the hypothesis that physical activity benefits immune status of the aged, and these improvements may be applied to generate positive clinical outcomes.

ISBN: 0496706024Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Aging and physical activity: Implications for human immune function and health.
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500 $a Director: Monika Fleshner.
502 $a Thesis (Ph.D.)--University of Colorado at Boulder, 2004.
520 $a The failing of the immune system in aging is characterized by a progressive decline in the antibody and T-cell mediated responses with a concurrent increase in inflammation. The chronically ill population suffers from a myriad of problems, including decreased endurance, mental health, activities of daily living, and balance. Maintaining a physically active lifestyle may mitigate these deficits. The purpose of this dissertation was to examine the role of physical activity on immune function and health status in older adults. Experiment 1 examined the influence of aging and physical activity on primary antibody and T-cell mediated immune responses by challenging subjects with the T-cell dependent protein keyhole-limpet hemocyanin (KLH). The results were that aging significantly reduced all anti-KLH measures except anti-KLH IgG2. Physically active older subjects had significantly improved anti-KLH IgM, IgG, IgG1, and DTH responses, but not IgG2, compared to sedentary older subjects. Experiment 2 tested if physical activity can influence heat shock proteins and inflammation in the aged. The results were that physically active groups had significantly elevated levels of HSP70 and significantly reduced levels of CRP. No significant differences were found in other markers of inflammation. Experiment 3 examined immune responses to KLH, as well as circulating inflammatory markers, in coronary artery disease (CAD) patients. Healthy older adults had a more robust anti-KLH IgM, IgG1 and DTH response than age-matched subjects with CAD. There were no differences in anti-KLH IgG, and IgG2 or in CRP, TNF-alpha, IL-6, IL-10, and cortisol. Experiment 4 applied these exercise principles to chronically ill patients. The physiological, health, and cost benefits of a comprehensive rehabilitation program were examined in medically complex patients. Physical functioning and mental health were assessed by the SF-36, and a medical event questionnaire was collected at baseline and after three months of the program. Strength measures improved by &sim;30% and aerobic power improved by &sim;25% over the three-month period. There were significant improvements in the SF-36 and significant reductions in fall rate, physician visits, and hospitalizations. Conclusion. Taken together, these findings support the hypothesis that physical activity benefits immune status of the aged, and these improvements may be applied to generate positive clinical outcomes.
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