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Nitrogen and oxygen radicals in isch...

Dobrucki, Wawrzyniec Lawrence.

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Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain./
作者:	Dobrucki, Wawrzyniec Lawrence.
面頁冊數:	158 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2164.
Contained By:	Dissertation Abstracts International64-05B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3089485
ISBN:	0496372171

Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain.
Dobrucki, Wawrzyniec Lawrence.

Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain. - 158 p.

Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2164.

Thesis (Ph.D.)--Ohio University, 2003.

The purpose of this work was to examine the role played by a deficit in nitric oxide (NO) and overproduction of superoxide ( O-2 ) and peroxynitrite (ONOO-) in contributing to the large cerebral infarcts seen in hypertensive and/or old animals. The role of NO-mediated mechanism in hypobaric hypoxia has been also studied. Additionally, the positive effect of the hypoxic adaptation on cerebral ischemia and reperfusion (I/R) has been demonstrated.

ISBN: 0496372171Subjects--Topical Terms:

586156
Chemistry, Analytical.

Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain.
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245 1 0 $a Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain.
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500 $a Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2164.
500 $a Director: Tadeusz Malinski.
502 $a Thesis (Ph.D.)--Ohio University, 2003.
520 $a The purpose of this work was to examine the role played by a deficit in nitric oxide (NO) and overproduction of superoxide ( O-2 ) and peroxynitrite (ONOO-) in contributing to the large cerebral infarcts seen in hypertensive and/or old animals. The role of NO-mediated mechanism in hypobaric hypoxia has been also studied. Additionally, the positive effect of the hypoxic adaptation on cerebral ischemia and reperfusion (I/R) has been demonstrated.
520 $a Cerebral infarction was produced in rats by occlusion of the middle cerebral artery followed by reperfusion. Studies were performed in animals of different age, genotype (spontaneously hypertensive stroke-prone), animals subjected to NO synthase blockade, and animals subjected to hypobaric hypoxia followed by adaptation process (30 days at 5,000 m above sea level).
520 $a NO and O-2 released in the brain were monitored using a set of specially designed microsensors with a 1 nM detection limit for both NO and O-2 .
520 $a The direct relationships between: ONOO- concentration and infarct size, age and infarct size, and between altitude and both NO and O-2 concentrations released from the brain, have been established. Moreover, new evidence has been presented that neuroprotective properties of adaptation to hypoxia are solely due to an increase in bioactive NO.
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