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Application of computational sequenc...

Angelopoulos, Spiros.

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Application of computational sequence and structure analysis to the description of protein function.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Application of computational sequence and structure analysis to the description of protein function./
Author:	Angelopoulos, Spiros.
Description:	125 p.
Notes:	Source: Dissertation Abstracts International, Volume: 68-03, Section: B, page: 1500.
Contained By:	Dissertation Abstracts International68-03B.
Subject:	Biology, Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3257295

Application of computational sequence and structure analysis to the description of protein function.
Angelopoulos, Spiros.

Application of computational sequence and structure analysis to the description of protein function. - 125 p.

Source: Dissertation Abstracts International, Volume: 68-03, Section: B, page: 1500.

Thesis (Ph.D.)--Mount Sinai School of Medicine of New York University, 2007.

Genome sequencing projects are producing large amounts of linear amino acid sequences. More than 2,000,000 protein sequences have been described. The challenge of the post-genomic era is to understand the biochemical functions and biological roles of these proteins. In this context, computational approaches to the analysis of protein sequences and structures have become highly relevant. In each of the three chapters of my thesis, I present one such computational approach that covers the analysis of protein sequences, the prediction of protein structure from sequence, and the derivation of phenotypic information from sequence and structure information. Specifically the thesis is divided into the following chapters:Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Application of computational sequence and structure analysis to the description of protein function.
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100 1 $a Angelopoulos, Spiros. $3 1924500
245 1 0 $a Application of computational sequence and structure analysis to the description of protein function.
300 $a 125 p.
500 $a Source: Dissertation Abstracts International, Volume: 68-03, Section: B, page: 1500.
500 $a Advisers: Roberto Sanchez; Diomedes E. Logothetis.
502 $a Thesis (Ph.D.)--Mount Sinai School of Medicine of New York University, 2007.
520 $a Genome sequencing projects are producing large amounts of linear amino acid sequences. More than 2,000,000 protein sequences have been described. The challenge of the post-genomic era is to understand the biochemical functions and biological roles of these proteins. In this context, computational approaches to the analysis of protein sequences and structures have become highly relevant. In each of the three chapters of my thesis, I present one such computational approach that covers the analysis of protein sequences, the prediction of protein structure from sequence, and the derivation of phenotypic information from sequence and structure information. Specifically the thesis is divided into the following chapters:
520 $a Chapter 1. Multivariate analysis of multiple sequence alignments. This chapter deals with the development of a fully automatic sequence-based analysis for functional residue detection and sequence classification.
520 $a Chapter 2. Comparative modeling of potassium inward rectifier channels. This chapter deals with the modeling of the three-dimensional cytoplasmic structure of potassium channels to achieve complete structural coverage of the family, and with the comparison of the electrostatic potentials derived from the models using a novel image-based method.
520 $a Chapter 3. Sequence and structure-based analysis of Fabry disease mutations. This chapter deals with the identification of features derived from the sequence and structure of alpha-galactosidase that allow for the prediction of the phenotype of Fabry disease related mutations.
590 $a School code: 1353.
650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Biophysics, Medical. $3 1017681
690 $a 0715
690 $a 0760
710 2 $a Mount Sinai School of Medicine of New York University. $3 1025278
773 0 $t Dissertation Abstracts International $g 68-03B.
790 1 0 $a Sanchez, Roberto, $e advisor
790 1 0 $a Logothetis, Diomedes E., $e advisor
790 $a 1353
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3257295