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Application of bone marrow stem cell...

Togel, Florian Erhard.

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Application of bone marrow stem cell biology in the treatment of acute renal failure.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Application of bone marrow stem cell biology in the treatment of acute renal failure./
作者:	Togel, Florian Erhard.
面頁冊數:	67 p.
附註:	Source: Dissertation Abstracts International, Volume: 67-03, Section: B, page: 1370.
Contained By:	Dissertation Abstracts International67-03B.
標題:	Health Sciences, Medicine and Surgery. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3209607
ISBN:	9780542580161

Application of bone marrow stem cell biology in the treatment of acute renal failure.
Togel, Florian Erhard.

Application of bone marrow stem cell biology in the treatment of acute renal failure. - 67 p.

Source: Dissertation Abstracts International, Volume: 67-03, Section: B, page: 1370.

Thesis (Ph.D.)--The University of Utah, 2006.

The physiology of an organ is critically affected in disease states and return to normal function can be accomplished only through restitution of the underlying organ physiology. While many organs possess remarkable capacities of restitution, some injuries are too severe and make this mechanism inefficient. Pharmacological approaches target only a certain aspect of the pathophysiology of a disease and many diseases are multifactorial so that these pharmacological approaches appear insufficient. These insufficiencies of pharmacotherapy can possibly be overcome by using cell therapeutic approaches that all enable targeting multiple causes of one particular complex disease, e.g., inflammatory and ischemic injuries with the same therapeutic agent.

ISBN: 9780542580161Subjects--Topical Terms:

1017756
Health Sciences, Medicine and Surgery.

Application of bone marrow stem cell biology in the treatment of acute renal failure.
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500 $a Adviser: Christof Westenfelder.
502 $a Thesis (Ph.D.)--The University of Utah, 2006.
520 $a The physiology of an organ is critically affected in disease states and return to normal function can be accomplished only through restitution of the underlying organ physiology. While many organs possess remarkable capacities of restitution, some injuries are too severe and make this mechanism inefficient. Pharmacological approaches target only a certain aspect of the pathophysiology of a disease and many diseases are multifactorial so that these pharmacological approaches appear insufficient. These insufficiencies of pharmacotherapy can possibly be overcome by using cell therapeutic approaches that all enable targeting multiple causes of one particular complex disease, e.g., inflammatory and ischemic injuries with the same therapeutic agent.
520 $a Stem cells are ideal vehicles for cell therapy because of their undifferentiated state and thereby resulting versatility to react to different pathophysiological conditions. Bone marrow (BM) derived stem cells are easily accessible in the autologous and allogeneic setting and their biology has been studied for more than 50 years, making them the most well-characterized adult stem cell population so far.
520 $a Acute renal failure (ARF) is a multifactorial syndrome associated with high clinical mortality and disease-specific therapeutic concepts beyond supportive therapy are currently not available. There are several important pathophysiological components of ARF: endothelial damage with subsequently impaired blood flow, inflammation and tubular cell death by apoptosis and necrosis, all contributing to a fall in the glomerular filtration fraction (GFR).
520 $a Due to this complex pattern of dysfunction during ARF we hypothesized that bone marrow derived stem cells might be a promising new treatment approach for ARF.
520 $a We found that hematopoietic stem cell mobilization by currently applied clinical protocols did not improve but actually worsened ischemia/reperfusion injury by concomitant granulocytosis. Signals involved in mobilization and homing of bone marrow derived cells include the chemokine Stromal cell-derived factor-1 (SDF-1), a so far unrecognized mediator of homing and migration of CXCR4 expressing cells in the injured kidney.
520 $a Mesenchymal stem cells from the bone marrow, when administered after ischemic injury, have robust renoprotective potential and enhance recovery from injury by differentiation independent mechanisms including growth factor secretion, vascular support and immunomodulation.
520 $a Our studies demonstrate the promising potential of BM derived stem cells for cell therapeutic approaches in ARF.
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