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Characterization of a murine model o...

Buttars, Stephen David.

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Characterization of a murine model of duct carcinoma in situ of the breast.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Characterization of a murine model of duct carcinoma in situ of the breast./
Author:	Buttars, Stephen David.
Description:	113 p.
Notes:	Source: Masters Abstracts International, Volume: 45-03, page: 1472.
Contained By:	Masters Abstracts International45-03.
Subject:	Health Sciences, Pathology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR21260
ISBN:	9780494212608

Characterization of a murine model of duct carcinoma in situ of the breast.
Buttars, Stephen David.

Characterization of a murine model of duct carcinoma in situ of the breast. - 113 p.

Source: Masters Abstracts International, Volume: 45-03, page: 1472.

Thesis (M.Sc.)--University of Toronto (Canada), 2006.

Duct carcinome in situ (DCIS), an alleged precursor of invasive breast cancer, is characterized by neoplastic epithelial cells growing within mammary ducts. Clinical prognostication for DCIS is challenging, as the likelihood of progression to invasion of individual lesions remains unclear. To circumvent issues surrounding the study of DCIS in humans, the MMTVneu202 mouse, previously reported to develop DCIS-like mammary lesions, was employed. Necropsied mouse mammary tumours were investigated using multiple approaches, beginning with morphological and histological assessment. A set of clinical and investigational immunohistochemical markers was applied to develop a tumour profile. Finally, DNA was extracted from fixed tumour tissue and examined using microarray comparative genomic hybridization. Results indicate that the MMTVneu202 mouse represents a useful model for the study of DCIS. Additionally, molecular differences between DCIS and invasive tumours have been identified which may be employed to further investigate the natural history and progression of DCIS.

ISBN: 9780494212608Subjects--Topical Terms:

1017854
Health Sciences, Pathology.

Characterization of a murine model of duct carcinoma in situ of the breast.
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100 1 $a Buttars, Stephen David. $3 1923194
245 1 0 $a Characterization of a murine model of duct carcinoma in situ of the breast.
300 $a 113 p.
500 $a Source: Masters Abstracts International, Volume: 45-03, page: 1472.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2006.
520 $a Duct carcinome in situ (DCIS), an alleged precursor of invasive breast cancer, is characterized by neoplastic epithelial cells growing within mammary ducts. Clinical prognostication for DCIS is challenging, as the likelihood of progression to invasion of individual lesions remains unclear. To circumvent issues surrounding the study of DCIS in humans, the MMTVneu202 mouse, previously reported to develop DCIS-like mammary lesions, was employed. Necropsied mouse mammary tumours were investigated using multiple approaches, beginning with morphological and histological assessment. A set of clinical and investigational immunohistochemical markers was applied to develop a tumour profile. Finally, DNA was extracted from fixed tumour tissue and examined using microarray comparative genomic hybridization. Results indicate that the MMTVneu202 mouse represents a useful model for the study of DCIS. Additionally, molecular differences between DCIS and invasive tumours have been identified which may be employed to further investigate the natural history and progression of DCIS.
590 $a School code: 0779.
650 4 $a Health Sciences, Pathology. $3 1017854
650 4 $a Biophysics, Medical. $3 1017681
690 $a 0571
690 $a 0760
710 2 0 $a University of Toronto (Canada). $3 1017674
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