東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Evaluation of models for microtubule...

Martinez Maldonado, Joel E.

FindBook

Google Book

Amazon

博客來

Evaluation of models for microtubule-based intracellular bi-directional transport.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Evaluation of models for microtubule-based intracellular bi-directional transport./
作者:	Martinez Maldonado, Joel E.
面頁冊數:	136 p.
附註:	Source: Dissertation Abstracts International, Volume: 67-09, Section: B, page: 5232.
Contained By:	Dissertation Abstracts International67-09B.
標題:	Biology, Cell. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3233397
ISBN:	9780542874796

Evaluation of models for microtubule-based intracellular bi-directional transport.
Martinez Maldonado, Joel E.

Evaluation of models for microtubule-based intracellular bi-directional transport. - 136 p.

Source: Dissertation Abstracts International, Volume: 67-09, Section: B, page: 5232.

Thesis (Ph.D.)--University of California, Irvine, 2006.

Motion is essential at every level of life. Inside cells, an intricate transport system diligently distributes organelles and molecules. Intracellular transport systems are involved in pathology, e.g. malfunction of intracellular transport is implicated in neurodegenerative diseases. Thus, understanding intracellular transport may contribute to the development of novel therapeutic approaches. Much of microtubule-based transport occurs in a bi-directional manner, i.e. cargos move towards their destination by alternating forward and backward motion. The effectors of cargo displacement are the microtubule motors dynein and kinesin. Opposite polarity motors, dynein and kinesin, are simultaneously bound to bi-directionally moving cargos and their function is coordinated. Recently it has been proposed that multiple same polarity motors cooperate to move a cargo faster. How does bi-directional transport result in net transport of cargos? How are motors turned on and off to achieve coordination? How do multiple motors cooperate? The current work is a study of the bi-directional transport of lipid droplets in the Drosophila embryo that partially addresses these questions. The first half of this work presents a detailed study of the types of motion observed in bi-directional transport. This work provides insight into the protein rearrangements that may occur in coordination and presents a functional model for lipid droplet bi-directional transport. The second half of this work focuses on the study of velocity within two motion types, plus and minus-end long runs, to investigate motor coordination and cooperation. Altogether, this work contributes to our understanding of how the properties of single moving lipid droplets result in net transport by eliminating several models for how bi-directional transport might occur and providing evidence for more likely models.

ISBN: 9780542874796Subjects--Topical Terms:

1017686
Biology, Cell.

Evaluation of models for microtubule-based intracellular bi-directional transport.
LDR:02812nmm 2200289 4500 001 1832104
005 20070628102713.5
008 130610s2006 eng d
020 $a 9780542874796
035 $a (UnM)AAI3233397
035 $a AAI3233397
040 $a UnM $c UnM
100 1 $a Martinez Maldonado, Joel E. $3 1920850
245 1 0 $a Evaluation of models for microtubule-based intracellular bi-directional transport.
300 $a 136 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-09, Section: B, page: 5232.
500 $a Adviser: Steven P. Gross.
502 $a Thesis (Ph.D.)--University of California, Irvine, 2006.
520 $a Motion is essential at every level of life. Inside cells, an intricate transport system diligently distributes organelles and molecules. Intracellular transport systems are involved in pathology, e.g. malfunction of intracellular transport is implicated in neurodegenerative diseases. Thus, understanding intracellular transport may contribute to the development of novel therapeutic approaches. Much of microtubule-based transport occurs in a bi-directional manner, i.e. cargos move towards their destination by alternating forward and backward motion. The effectors of cargo displacement are the microtubule motors dynein and kinesin. Opposite polarity motors, dynein and kinesin, are simultaneously bound to bi-directionally moving cargos and their function is coordinated. Recently it has been proposed that multiple same polarity motors cooperate to move a cargo faster. How does bi-directional transport result in net transport of cargos? How are motors turned on and off to achieve coordination? How do multiple motors cooperate? The current work is a study of the bi-directional transport of lipid droplets in the Drosophila embryo that partially addresses these questions. The first half of this work presents a detailed study of the types of motion observed in bi-directional transport. This work provides insight into the protein rearrangements that may occur in coordination and presents a functional model for lipid droplet bi-directional transport. The second half of this work focuses on the study of velocity within two motion types, plus and minus-end long runs, to investigate motor coordination and cooperation. Altogether, this work contributes to our understanding of how the properties of single moving lipid droplets result in net transport by eliminating several models for how bi-directional transport might occur and providing evidence for more likely models.
590 $a School code: 0030.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biophysics, General. $3 1019105
690 $a 0379
690 $a 0541
690 $a 0786
710 2 0 $a University of California, Irvine. $3 705821
773 0 $t Dissertation Abstracts International $g 67-09B.
790 1 0 $a Gross, Steven P., $e advisor
790 $a 0030
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3233397