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Investigation of skin and skin compo...

Yuan, Ye.

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Investigation of skin and skin components using polarized fluorescence and polarized reflectance towards the detection of cutaneous melanoma.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Investigation of skin and skin components using polarized fluorescence and polarized reflectance towards the detection of cutaneous melanoma./
作者:	Yuan, Ye.
面頁冊數:	164 p.
附註:	Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2702.
Contained By:	Dissertation Abstracts International67-05B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3218757
ISBN:	9780542704390

Investigation of skin and skin components using polarized fluorescence and polarized reflectance towards the detection of cutaneous melanoma.
Yuan, Ye.

Investigation of skin and skin components using polarized fluorescence and polarized reflectance towards the detection of cutaneous melanoma. - 164 p.

Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2702.

Thesis (Ph.D.)--The University of Toledo, 2006.

In an effort to investigate viability of using autofluorescence to detect superficial skin cancer (melanoma), polarized fluorescence spectroscopy was employed with the goal of reducing the contribution of the background fluorescence generated from the deep skin. Polarized reflectance was also employed to account for the effects of tissue scattering and absorption on the polarized fluorescence measurements and to measure changes in tissue scattering.

ISBN: 9780542704390Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Investigation of skin and skin components using polarized fluorescence and polarized reflectance towards the detection of cutaneous melanoma.
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245 1 0 $a Investigation of skin and skin components using polarized fluorescence and polarized reflectance towards the detection of cutaneous melanoma.
300 $a 164 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2702.
500 $a Adviser: Patricia Relue.
502 $a Thesis (Ph.D.)--The University of Toledo, 2006.
520 $a In an effort to investigate viability of using autofluorescence to detect superficial skin cancer (melanoma), polarized fluorescence spectroscopy was employed with the goal of reducing the contribution of the background fluorescence generated from the deep skin. Polarized reflectance was also employed to account for the effects of tissue scattering and absorption on the polarized fluorescence measurements and to measure changes in tissue scattering.
520 $a An investigation of the skin and its layers using polarized fluorescence spectroscopy has revealed that polarized fluorescence can be generated from the skin, the epidermis, and the dermis using polarized excitation light. The epidermis has the highest retention of fluorescence polarization, while the dermis has the lowest retention of fluorescence polarization. The dependence of the fluorescence anisotropy (a measurement of fluorescence polarization) on dermal thickness was measured, suggesting a role for multiple scattering within the dermis in the depolarization of fluorescence in both the dermis and the skin.
520 $a A hypothesis of NADH binding change resulting from a metabolic shift in cancer cells was presented. An investigation of normal human melanocytes and melanoma cells using fluorescence anisotropy of the NADH within the cells yielded results consistent with this hypothesis. Normal melanocytes show appreciably higher fluorescence anisotropy than melanoma cells.
520 $a Since dermal matrix erosion is one of the early stage events in cancer progression, an experimental system was developed to mimic tumor invasion. The process of the enzymatic erosion was investigated with polarized fluorescence, non-polarized fluorescence and polarized reflectance spectroscopy to provide insight into the contrasts between the normal and enzyme-digested dermal matrix. The degradation of the dermal matrix with enzymes results in a decrease in fluorescence emission and light scattering in the matrix. These results confirm the suggestion from literature studies with whole tissue that collagenase-induced dissolution of the extracellular matrix is the cause of the reduction of the fluorescence emission and scattering of the malignant tissue. Fluorescence anisotropy, however, cannot detect the change in the dermal matrix induced by enzyme digestion. It appears that enzymatic digestion does not change the physicochemical properties of the remaining fluorophores and their microenvironment in the dermis.
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