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Phosphorylation of herpes simplex vi...

Provencher, Veronic Marie Isabelle.

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Phosphorylation of herpes simplex virus type-1 immediate-early protein ICP4 is required for its recruitment to nuclear replication compartments.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Phosphorylation of herpes simplex virus type-1 immediate-early protein ICP4 is required for its recruitment to nuclear replication compartments./
作者:	Provencher, Veronic Marie Isabelle.
面頁冊數:	193 p.
附註:	Source: Masters Abstracts International, Volume: 44-05, page: 2221.
Contained By:	Masters Abstracts International44-05.
標題:	Biology, Molecular. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR13876
ISBN:	9780494138762

Phosphorylation of herpes simplex virus type-1 immediate-early protein ICP4 is required for its recruitment to nuclear replication compartments.
Provencher, Veronic Marie Isabelle.

Phosphorylation of herpes simplex virus type-1 immediate-early protein ICP4 is required for its recruitment to nuclear replication compartments. - 193 p.

Source: Masters Abstracts International, Volume: 44-05, page: 2221.

Thesis (M.Sc.)--University of Alberta (Canada), 2006.

The nuclear domains in which herpes simplex type-1 (HSV-1) genomes are transcribed and replicated are called replication compartments (RCs). RCs contain seven HSV-1 DNA replication proteins, two HSV-1 transcription regulators (ICP4 and ICP27), HSV-1 genomes, and selected cellular proteins. Pre-replication compartments (pre-RCs) are smaller domains formed early in infection containing the same viral proteins but not HSV-1 genomes. A subset of pre-RCs are thought to be the precursors of RCs. The immediate-early phosphoprotein ICP4 may be recruited to the pre-RCs or RCs by the ICP4 binding sites in the HSV-1 genomes, or by binding to proteins at the core of these compartments. ICP4 phosphorylation is required for its transcriptional regulatory activation, but not for its DNA binding activity. It is yet unknown whether ICP4 phosphorylation is required for its recruitment into RCs. My hypothesis is that ICP4 phosphorylation is required for its recruitment into RCs. A cyclin-dependent kinase (CDK) inhibitor, roscovitine, inhibits ICP4 phosphorylation. (Abstract shortened by UMI.)

ISBN: 9780494138762Subjects--Topical Terms:

1017719
Biology, Molecular.

Phosphorylation of herpes simplex virus type-1 immediate-early protein ICP4 is required for its recruitment to nuclear replication compartments.
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520 $a The nuclear domains in which herpes simplex type-1 (HSV-1) genomes are transcribed and replicated are called replication compartments (RCs). RCs contain seven HSV-1 DNA replication proteins, two HSV-1 transcription regulators (ICP4 and ICP27), HSV-1 genomes, and selected cellular proteins. Pre-replication compartments (pre-RCs) are smaller domains formed early in infection containing the same viral proteins but not HSV-1 genomes. A subset of pre-RCs are thought to be the precursors of RCs. The immediate-early phosphoprotein ICP4 may be recruited to the pre-RCs or RCs by the ICP4 binding sites in the HSV-1 genomes, or by binding to proteins at the core of these compartments. ICP4 phosphorylation is required for its transcriptional regulatory activation, but not for its DNA binding activity. It is yet unknown whether ICP4 phosphorylation is required for its recruitment into RCs. My hypothesis is that ICP4 phosphorylation is required for its recruitment into RCs. A cyclin-dependent kinase (CDK) inhibitor, roscovitine, inhibits ICP4 phosphorylation. (Abstract shortened by UMI.)
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