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B lymphocyte expression of cyclooxyg...

Ryan, Elizabeth Pansy.

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B lymphocyte expression of cyclooxygenase-2: Implications for humoral immunity and cancer.

Record Type:	Electronic resources : Monograph/item
Title/Author:	B lymphocyte expression of cyclooxygenase-2: Implications for humoral immunity and cancer./
Author:	Ryan, Elizabeth Pansy.
Description:	203 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3101.
Contained By:	Dissertation Abstracts International67-06B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3222109
ISBN:	9780542726231

B lymphocyte expression of cyclooxygenase-2: Implications for humoral immunity and cancer.
Ryan, Elizabeth Pansy.

B lymphocyte expression of cyclooxygenase-2: Implications for humoral immunity and cancer. - 203 p.

Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3101.

Thesis (Ph.D.)--University of Rochester, 2006.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of inflammatory diseases and target cyclooxygenases 1 and 2 (Cox-1, Cox-2) that are responsible for prostaglandin (PG) production. Newer Cox-2-selective drugs are heavily prescribed to quench inflammation. Little is known about whether or not these drugs influence B lineage cells. Initial studies in this thesis first characterized Cox-2 expression and PG production by both normal and malignant human B lineage cells. The role of Cox-2 in promoting humoral immune responses was investigated using both nonselective and selective Cox-2 inhibitors, as well as a genetic mouse model of Cox-2 deficiency. Activated human B lymphocytes not only highly express Cox-2 and produce PGs, but the NSAID Indomethacin and Cox-2 selective drugs profoundly inhibit the ability of human B cells to produce IgG and IgM in vitro . In support that Cox-2 plays a seminal role in B lymphocyte antibody production, Cox-2 knock out mice produced significantly less serum IgG in response to human papillomavirus type 16 virus-like-particles compared to wildtype mice. Taken together, these findings support that NSAIDs and the new Cox-2 selective drugs have an unsuspected target, the B cell, and may attenuate antibody production in humans.

ISBN: 9780542726231Subjects--Topical Terms:

1017686
Biology, Cell.

B lymphocyte expression of cyclooxygenase-2: Implications for humoral immunity and cancer.
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100 1 $a Ryan, Elizabeth Pansy. $3 1919860
245 1 0 $a B lymphocyte expression of cyclooxygenase-2: Implications for humoral immunity and cancer.
300 $a 203 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3101.
500 $a Adviser: Richard P. Phipps.
502 $a Thesis (Ph.D.)--University of Rochester, 2006.
520 $a Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of inflammatory diseases and target cyclooxygenases 1 and 2 (Cox-1, Cox-2) that are responsible for prostaglandin (PG) production. Newer Cox-2-selective drugs are heavily prescribed to quench inflammation. Little is known about whether or not these drugs influence B lineage cells. Initial studies in this thesis first characterized Cox-2 expression and PG production by both normal and malignant human B lineage cells. The role of Cox-2 in promoting humoral immune responses was investigated using both nonselective and selective Cox-2 inhibitors, as well as a genetic mouse model of Cox-2 deficiency. Activated human B lymphocytes not only highly express Cox-2 and produce PGs, but the NSAID Indomethacin and Cox-2 selective drugs profoundly inhibit the ability of human B cells to produce IgG and IgM in vitro . In support that Cox-2 plays a seminal role in B lymphocyte antibody production, Cox-2 knock out mice produced significantly less serum IgG in response to human papillomavirus type 16 virus-like-particles compared to wildtype mice. Taken together, these findings support that NSAIDs and the new Cox-2 selective drugs have an unsuspected target, the B cell, and may attenuate antibody production in humans.
520 $a It was also established that certain B lymphomas and chronic lymphocytic leukemia B cells (B-CLL) constitutively express Cox-2. Constitutive and activation-inducible Cox-2 expression has prognostic value as a subgroup of B-CLL samples with biomarkers of poor prognosis, namely variable heavy chain mutational status and elevated CD38 expression demonstrated elevated levels of Cox-2. Furthermore, modulation of intracellular thiol redox status was evaluated as the mechanism by which SC-58125, a close structural analog of Celebrex, and a highly Cox-2 selective inhibitor, reduced malignant B cell proliferation and viability. Our findings confirm that Cox-2 promotes lymphoma/leukemic cell survival and support that Cox-2 selective inhibitors are potential therapeutic agents to control malignant human B cell proliferation and possibly metastasis in vivo.
590 $a School code: 0188.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Toxicology. $3 1017752
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Health Sciences, Oncology. $3 1018566
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710 2 0 $a University of Rochester. $3 515736
773 0 $t Dissertation Abstracts International $g 67-06B.
790 1 0 $a Phipps, Richard P., $e advisor
790 $a 0188
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3222109