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Antigen processing in the endoplasmi...

Hammer, Gianna Elena.

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Antigen processing in the endoplasmic reticulum for MHC class I molecules.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Antigen processing in the endoplasmic reticulum for MHC class I molecules./
Author:	Hammer, Gianna Elena.
Description:	131 p.
Notes:	Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 0876.
Contained By:	Dissertation Abstracts International68-02B.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3253887

Antigen processing in the endoplasmic reticulum for MHC class I molecules.
Hammer, Gianna Elena.

Antigen processing in the endoplasmic reticulum for MHC class I molecules. - 131 p.

Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 0876.

Thesis (Ph.D.)--University of California, Berkeley, 2006.

CD8 T cell development and immune responsiveness is dependent on Major Histocompatibility Complex class I molecules (MHC I) to present a diverse spectrum of peptides derived from intracellular proteins. Antigenic precursors are degraded in the cytoplasm and MHC I are loaded with peptides in the endoplasmic reticulum (ER). In this compartment, peptides can be trimmed at the N-terminus by the ER aminopeptidase associated with antigen processing (ERAAP). However, the extent to which the peptide pool requires trimming and how ERAAP shapes the peptide repertoire displayed by MHC I (pMHC I) is not known. To address these questions we generated ERAAP deficient mice by homologous recombination. We found that in the absence of ERAAP, peptides are not trimmed in the ER and based upon customization by ERAAP, peptides can be divided into three subsets. Some peptides are generated independently of ERAAP, while others enter the ER with N-terminal extensions and require ERAAP for processing. Another subset of peptides are sensitive to ERAAP and are dramatically upregulated in its absence.Subjects--Topical Terms:

1017734
Biology, Microbiology.

Antigen processing in the endoplasmic reticulum for MHC class I molecules.
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035 $a (UMI)AAI3253887
035 $a AAI3253887
040 $a UMI $c UMI
100 1 $a Hammer, Gianna Elena. $3 1918015
245 1 0 $a Antigen processing in the endoplasmic reticulum for MHC class I molecules.
300 $a 131 p.
500 $a Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 0876.
500 $a Adviser: Nilabh Shastri.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2006.
520 $a CD8 T cell development and immune responsiveness is dependent on Major Histocompatibility Complex class I molecules (MHC I) to present a diverse spectrum of peptides derived from intracellular proteins. Antigenic precursors are degraded in the cytoplasm and MHC I are loaded with peptides in the endoplasmic reticulum (ER). In this compartment, peptides can be trimmed at the N-terminus by the ER aminopeptidase associated with antigen processing (ERAAP). However, the extent to which the peptide pool requires trimming and how ERAAP shapes the peptide repertoire displayed by MHC I (pMHC I) is not known. To address these questions we generated ERAAP deficient mice by homologous recombination. We found that in the absence of ERAAP, peptides are not trimmed in the ER and based upon customization by ERAAP, peptides can be divided into three subsets. Some peptides are generated independently of ERAAP, while others enter the ER with N-terminal extensions and require ERAAP for processing. Another subset of peptides are sensitive to ERAAP and are dramatically upregulated in its absence.
520 $a Dearth of N-terminal trimming in the ER does not starve MHC I of peptide supply. Instead, a surprisingly large volume of untrimmed peptides are presented as unique pMHC I complexes at the cell surface of ERAAP deficient cells. These pMHC I are unstable but immunologically and structurally unique and elicit potent T cell and B cell responses in wild-type mice. Thus, ERAAP is a quintessential editor of the MHC I peptide repertoire and paradoxically its absence enhances immunogenicity.
590 $a School code: 0028.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0410
690 $a 0982
710 2 0 $a University of California, Berkeley. $3 687832
773 0 $t Dissertation Abstracts International $g 68-02B.
790 1 0 $a Shastri, Nilabh, $e advisor
790 $a 0028
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3253887