東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Essays on the management of clinical...

Zinner, Darren E.

FindBook

Google Book

Amazon

博客來

Essays on the management of clinical trial sites: Lessons for health policy, technology development, and organizational theory.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Essays on the management of clinical trial sites: Lessons for health policy, technology development, and organizational theory./
作者:	Zinner, Darren E.
面頁冊數:	115 p.
附註:	Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2457.
Contained By:	Dissertation Abstracts International67-05B.
標題:	Health Sciences, Pharmacy. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3217949
ISBN:	9780542694745

Essays on the management of clinical trial sites: Lessons for health policy, technology development, and organizational theory.
Zinner, Darren E.

Essays on the management of clinical trial sites: Lessons for health policy, technology development, and organizational theory. - 115 p.

Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2457.

Thesis (Ph.D.)--Harvard University, 2006.

Changes in the costs and complexities of developing new pharmaceuticals have led to transformations in the clinical research industry. The influx of new types of research sites and principal investigators has created substantial differences in how clinical research studies are conducted and managed.

ISBN: 9780542694745Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Essays on the management of clinical trial sites: Lessons for health policy, technology development, and organizational theory.
LDR:03419nmm 2200313 4500 001 1829052
005 20071106080113.5
008 130610s2006 eng d
020 $a 9780542694745
035 $a (UMI)AAI3217949
035 $a AAI3217949
040 $a UMI $c UMI
100 1 $a Zinner, Darren E. $3 1917922
245 1 0 $a Essays on the management of clinical trial sites: Lessons for health policy, technology development, and organizational theory.
300 $a 115 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2457.
500 $a Adviser: Gary Pisano.
502 $a Thesis (Ph.D.)--Harvard University, 2006.
520 $a Changes in the costs and complexities of developing new pharmaceuticals have led to transformations in the clinical research industry. The influx of new types of research sites and principal investigators has created substantial differences in how clinical research studies are conducted and managed.
520 $a This research thesis utilizes the homogeneity of clinical research tasks across sites, while exploiting the structural variation among these different types of investigative centers. Within a given trial, multiple investigators recruit identically eligible volunteers, enroll them into a common clinical protocol, and process them according to the same quality specifications. Yet, these sites differ in important organizational and demographic characteristics. Using proprietary benchmark data from biopharmaceutical sponsors and a clinical research services firm, I utilize multivariate regression analysis with protocol-level fixed effects to determine the characteristics that predict site-level clinical trial enrollment. My research is divided into three separate papers that seek to provide lessons for clinical research, health policy, and organizational theory.
520 $a Paper one documents that conducting clinical research requires administrative focus and coordination, suggesting that managerial and organizational characteristics of investigative sites have a large impact on the final enrollment tallies. Thus, policies aimed at improving the productivity of the clinical development process, such as the National Institutes of Health's Roadmap for Medical Research, should also focus on the managerial issues surrounding clinical research. Paper two uses geographic variation across trial sites to show that the uninsured are disproportionately enrolling in industry-sponsored clinical trials, confirming the existence of a hole in the nation's safety-net provider system. Lastly, paper three seeks to inform the management of diversified firms by exploring the effect of operational focus on productivity. It finds that sites that focus on conducting clinical trials significantly outperform those that mix trial activity with the provision of traditional patient care. However, diversified sites that separate clinical trial activity and traditional patient care through a "plant-within-a-plant" structure achieve performance that is statistically equivalent to that of a fully focused site dedicated solely to clinical trials.
590 $a School code: 0084.
650 4 $a Health Sciences, Pharmacy. $3 1017737
650 4 $a Political Science, Public Administration. $3 1017438
650 4 $a Health Sciences, Health Care Management. $3 1017922
690 $a 0572
690 $a 0617
690 $a 0769
710 2 0 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 67-05B.
790 1 0 $a Pisano, Gary, $e advisor
790 $a 0084
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3217949