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Human papillomavirus in head and nec...

Furniss, Constance Sloane.

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Human papillomavirus in head and neck squamous cell carcinoma.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Human papillomavirus in head and neck squamous cell carcinoma./
作者:	Furniss, Constance Sloane.
面頁冊數:	124 p.
附註:	Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2352.
Contained By:	Dissertation Abstracts International67-05B.
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3217727
ISBN:	9780542692444

Human papillomavirus in head and neck squamous cell carcinoma.
Furniss, Constance Sloane.

Human papillomavirus in head and neck squamous cell carcinoma. - 124 p.

Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2352.

Thesis (Ph.D.)--Harvard University, 2006.

The discovery of human papillomavirus (HPV) as a necessary cause of cervical cancer in the 1980's was a great stride in the field of tumor viruses. HPV is now known to cause almost 100% of cervical cancers and during the last two decades, has also been implicated in 20-25% of head and neck squamous cell carcinomas (HNSCC). Unlike cervical cancer, where viral presence is the prominent risk factor, the role of HPV in oral cancers appears to be more complex, as oral cancers have been associated predominantly with alcohol and tobacco exposure. Also unknown is whether HPV is associated with changes in genomic instability in HNSCC. We examined the association of HPV16 DNA and risk for HNSCC in a case only study and that between HPV serology and risk for HNSCC in a case-control study, examining the association between HPV and alcohol and tobacco consumption, patient demographics, and clinical correlates such as tumor location and patient survival. In a case only analysis of HNSCC, we also studied the relationship between viral presence and LINE-1 hypomethylation, a measure of genomic instability in the tumor. We assessed HPV16 DNA status by PCR-amplification of a region of the L1 gene of HPV16. Serology to the L1 protein of HPV6, 11, 16 and 18 was determined by the competitive luminex immunoassay. LINE-1 hypomethylation was measured by PCR amplification of the LINE-1 promoter region, followed by restriction digests. We found that HPV16 DNA was prevalent in 25% of HNSCC cases and was associated with lighter drinking behavior. Antibodies to HPV6 and HPV 16 were associated with increased risk for HNSCC. Among cases, both HPV16 DNA and serology to L1 were associated with an increasing number of oral sex partners, better patient survival, and oropharyngeal location. Hypomethylation of LINE-1 was not associated with HPV status but was associated with smoking and drinking behaviors, gene specific promoter hypermethylation and p53 status. We have shown evidence supporting the idea that HPV6 and HPV16 are important risk factors for HNSCC and that changes in genomic instability may account for distinct clinical and molecular characteristics of HNSCC tumors.

ISBN: 9780542692444Subjects--Topical Terms:

1017734
Biology, Microbiology.

Human papillomavirus in head and neck squamous cell carcinoma.
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