東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

A mutagenesis approach to study the ...

Peng, Wei.

Linked to FindBook

Google Book

Amazon

博客來

A mutagenesis approach to study the molecules involved in CD1 antigen presentation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A mutagenesis approach to study the molecules involved in CD1 antigen presentation./
Author:	Peng, Wei.
Description:	179 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0798.
Contained By:	Dissertation Abstracts International67-02B.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3205941
ISBN:	9780542549441

A mutagenesis approach to study the molecules involved in CD1 antigen presentation.
Peng, Wei.

A mutagenesis approach to study the molecules involved in CD1 antigen presentation. - 179 p.

Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0798.

Thesis (Ph.D.)--Harvard University, 2006.

CD1 molecules area family of beta2-microglobulin (beta2m)-associated, nonpolymorphic cell surface glycoproteins which are capable of presenting lipid antigens. However, unlike the molecules involved in peptide antigen presentation, which have been extensively characterized, the components of CD1 antigen-presenting pathway are largely unknown. This dissertation has successfully used retrovirus insertion mutagenesis to generate a library of mutants which had lost one or more CD1 isoforms on cell surface, implying a deficiency in molecules that may be important in CD1 antigen presentation. In one of the mutants selected for further characterization, the heavy chains of all four CD1 molecules and class I MHC were missing from the cell surface, and two viral insertions were localized near beta2m, which a 12-kDa protein. Our present study has shown conclusively that all four CD1 isoforms depend on P2m for surface expression in an immune cell. Furthermore, different CD1 isoforms may have different affinities for beta2 m. This in turn might affect the immunological functions known to be carried out by each CD1 molecule.

ISBN: 9780542549441Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

A mutagenesis approach to study the molecules involved in CD1 antigen presentation.
LDR:01999nmm 2200265 4500 001 1828999
005 20071106080059.5
008 130610s2006 eng d
020 $a 9780542549441
035 $a (UMI)AAI3205941
035 $a AAI3205941
040 $a UMI $c UMI
100 1 $a Peng, Wei. $3 1291863
245 1 2 $a A mutagenesis approach to study the molecules involved in CD1 antigen presentation.
300 $a 179 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0798.
500 $a Adviser: Michael Brenner.
502 $a Thesis (Ph.D.)--Harvard University, 2006.
520 $a CD1 molecules area family of beta2-microglobulin (beta2m)-associated, nonpolymorphic cell surface glycoproteins which are capable of presenting lipid antigens. However, unlike the molecules involved in peptide antigen presentation, which have been extensively characterized, the components of CD1 antigen-presenting pathway are largely unknown. This dissertation has successfully used retrovirus insertion mutagenesis to generate a library of mutants which had lost one or more CD1 isoforms on cell surface, implying a deficiency in molecules that may be important in CD1 antigen presentation. In one of the mutants selected for further characterization, the heavy chains of all four CD1 molecules and class I MHC were missing from the cell surface, and two viral insertions were localized near beta2m, which a 12-kDa protein. Our present study has shown conclusively that all four CD1 isoforms depend on P2m for surface expression in an immune cell. Furthermore, different CD1 isoforms may have different affinities for beta2 m. This in turn might affect the immunological functions known to be carried out by each CD1 molecule.
590 $a School code: 0084.
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0982
710 2 0 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 67-02B.
790 1 0 $a Brenner, Michael, $e advisor
790 $a 0084
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3205941