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A mutagenesis approach to study the ...

Peng, Wei.

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A mutagenesis approach to study the molecules involved in CD1 antigen presentation.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	A mutagenesis approach to study the molecules involved in CD1 antigen presentation./
作者:	Peng, Wei.
面頁冊數:	179 p.
附註:	Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0798.
Contained By:	Dissertation Abstracts International67-02B.
標題:	Health Sciences, Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3205941
ISBN:	9780542549441

A mutagenesis approach to study the molecules involved in CD1 antigen presentation.
Peng, Wei.

A mutagenesis approach to study the molecules involved in CD1 antigen presentation. - 179 p.

Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0798.

Thesis (Ph.D.)--Harvard University, 2006.

CD1 molecules area family of beta2-microglobulin (beta2m)-associated, nonpolymorphic cell surface glycoproteins which are capable of presenting lipid antigens. However, unlike the molecules involved in peptide antigen presentation, which have been extensively characterized, the components of CD1 antigen-presenting pathway are largely unknown. This dissertation has successfully used retrovirus insertion mutagenesis to generate a library of mutants which had lost one or more CD1 isoforms on cell surface, implying a deficiency in molecules that may be important in CD1 antigen presentation. In one of the mutants selected for further characterization, the heavy chains of all four CD1 molecules and class I MHC were missing from the cell surface, and two viral insertions were localized near beta2m, which a 12-kDa protein. Our present study has shown conclusively that all four CD1 isoforms depend on P2m for surface expression in an immune cell. Furthermore, different CD1 isoforms may have different affinities for beta2 m. This in turn might affect the immunological functions known to be carried out by each CD1 molecule.

ISBN: 9780542549441Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

A mutagenesis approach to study the molecules involved in CD1 antigen presentation.
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