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Pharmacological modulation of nicoti...

Henigan, O'Neak C.

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Pharmacological modulation of nicotine dependence in the rat.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Pharmacological modulation of nicotine dependence in the rat./
作者:	Henigan, O'Neak C.
面頁冊數:	34 p.
附註:	Source: Masters Abstracts International, Volume: 44-02, page: 1054.
Contained By:	Masters Abstracts International44-02.
標題:	Psychology, Experimental. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1428611
ISBN:	9780542278945

Pharmacological modulation of nicotine dependence in the rat.
Henigan, O'Neak C.

Pharmacological modulation of nicotine dependence in the rat. - 34 p.

Source: Masters Abstracts International, Volume: 44-02, page: 1054.

Thesis (M.A.)--University of Houston-Clear Lake, 2005.

Nicotine has been under investigation to determine why it's so habit forming and to develop effective therapies to reduce addiction. While nicotine replacement therapy is the lead treatment for combating nicotine addiction, it has a high relapse rate, and other treatments are needed to decrease this rate. Correlations between nicotine addiction and depression have given rise to research on anti-depressants as treatment for dependence. The atypical anti-depressant, Bupropion, is reported to reduce nicotine dependence and is effective in smoking cessation. The effectiveness of bupropion has prompted the study of various other antidepressants to see if they also effectively decrease dependence. Nortriptyline, a tricyclic anti-depressant, was investigated here to determine its effectiveness at reducing nicotine dependence as indicated by reduction of abstinence syndrome precipitated by a nicotine antagonist. Nortriptyline pre-treatment did significantly decrease precipitated withdrawal signs in the rat, thus anti-depressants other than bupropion may be effective in assisting with smoking cessation.

ISBN: 9780542278945Subjects--Topical Terms:

517106
Psychology, Experimental.

Pharmacological modulation of nicotine dependence in the rat.
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