東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Non-steroidal anti-inflammatory drug...

Szekely, Christine Anna.

FindBook

Google Book

Amazon

博客來

Non-steroidal anti-inflammatory drugs and the risk of Alzheimer's disease.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Non-steroidal anti-inflammatory drugs and the risk of Alzheimer's disease./
作者:	Szekely, Christine Anna.
面頁冊數:	153 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6563.
Contained By:	Dissertation Abstracts International66-12B.
標題:	Health Sciences, Public Health. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3197234
ISBN:	9780542430640

Non-steroidal anti-inflammatory drugs and the risk of Alzheimer's disease.
Szekely, Christine Anna.

Non-steroidal anti-inflammatory drugs and the risk of Alzheimer's disease. - 153 p.

Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6563.

Thesis (Ph.D.)--The Johns Hopkins University, 2006.

Results of epidemiological studies indicate that non-aspirin non-steroidal anti-inflammatory drug (NSAID) use may reduce the risk of Alzheimer's Disease (AD). Although evidence from animal models of the disease supports this association, recent in vivo and in vitro investigations suggest that not all NSAIDs reduce AD pathology and that risk reduction may depend on the ability of the MAID to lower the 42 amino acid peptide amyloid beta (AN4). Attempts have been made to confirm these findings in humans by analyzing epidemiologic data, but it appears that no single study has sufficient numbers to address the issue adequately.

ISBN: 9780542430640Subjects--Topical Terms:

1017659
Health Sciences, Public Health.

Non-steroidal anti-inflammatory drugs and the risk of Alzheimer's disease.
LDR:03127nmm 2200313 4500 001 1826586
005 20061227115702.5
008 130610s2006 eng d
020 $a 9780542430640
035 $a (UnM)AAI3197234
035 $a AAI3197234
040 $a UnM $c UnM
100 1 $a Szekely, Christine Anna. $3 1915546
245 1 0 $a Non-steroidal anti-inflammatory drugs and the risk of Alzheimer's disease.
300 $a 153 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6563.
500 $a Adviser: Curtis L. Meinert.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2006.
520 $a Results of epidemiological studies indicate that non-aspirin non-steroidal anti-inflammatory drug (NSAID) use may reduce the risk of Alzheimer's Disease (AD). Although evidence from animal models of the disease supports this association, recent in vivo and in vitro investigations suggest that not all NSAIDs reduce AD pathology and that risk reduction may depend on the ability of the MAID to lower the 42 amino acid peptide amyloid beta (AN4). Attempts have been made to confirm these findings in humans by analyzing epidemiologic data, but it appears that no single study has sufficient numbers to address the issue adequately.
520 $a The aims of this dissertation were to (1) conduct a systematic review and meta-analysis of the epidemiologic literature on the relationship between NSAID use and AD to summarize the current state of knowledge on this relationship and (2) pool data from published prospective studies of NSAIDs and AD to carry out an individual-patient-data meta-analysis on whether the relationship with AD differs for NSAIDs depending upon their purported Abeta42-lowering effect.
520 $a The results of the systematic review and meta-analysis indicated a reduced risk of AD with NSAID exposure for non-prospective (OR=0.51, 95% CI=0.40-0.66) and prospective (RR=0.74, 95% CI=0.62-0.89) studies. Individual-level data from three prospective studies included in the systematic review were pooled, with a resulting HR of 0.67 (95% CI=0.510.89). These results did not vary based on classification of NSAIDs into those that lower Abeta42 in vivo or in vitro and those that do not (LRT > 0.05). The risk was similar for ibuprofen, the most commonly used Abeta 42 lowering NSAID (HR=0.69, 95% CI=0.46-1.04) and naproxen, the most commonly used non-Abeta42-lowering NSAID (HR=0.60, 95% CI=0.341.09). There was a slight risk reduction in aspirin users (HR=0.83, 95% CI=0.65-1.05) but no risk reduction in acetaminophen users (HR=0.97, 95% CI=0.71-1.33). There was a suggestion that arthritis may play an independent role in AD but this finding needs further investigation. These findings have implications for future prevention trials on AD and for public prevention strategies.
590 $a School code: 0098.
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Health Sciences, Mental Health. $3 1017693
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0573
690 $a 0347
690 $a 0419
710 2 0 $a The Johns Hopkins University. $3 1017431
773 0 $t Dissertation Abstracts International $g 66-12B.
790 1 0 $a Meinert, Curtis L., $e advisor
790 $a 0098
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3197234