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Effect of anthocyanin-rich extracts ...

Su, Ye.

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Effect of anthocyanin-rich extracts on 5-flurouracil chemotherapy.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effect of anthocyanin-rich extracts on 5-flurouracil chemotherapy./
Author:	Su, Ye.
Description:	101 p.
Notes:	Source: Masters Abstracts International, Volume: 44-04, page: 1718.
Contained By:	Masters Abstracts International44-04.
Subject:	Agriculture, Food Science and Technology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1431592
ISBN:	9780542476976

Effect of anthocyanin-rich extracts on 5-flurouracil chemotherapy.
Su, Ye.

Effect of anthocyanin-rich extracts on 5-flurouracil chemotherapy. - 101 p.

Source: Masters Abstracts International, Volume: 44-04, page: 1718.

Thesis (M.S.)--University of Maryland, College Park, 2006.

Anthocyanins are natural colorants, with potential chemopreventive activity. 5-Flurouracil (5-Fu) is a widely used cancer chemotherapeutic drug. However, it has serious side effects. Objective. To determine whether anthocyanin-rich-extracts (ARE) can increase the effectiveness of 5-Fu. Methods. Colon cancer cells were treated with ARE in combination with 5-Fu to assess in vitro whether ARE would enhance 5-Fu cytotoxicity. In vivo, rats were given diets with or without ARE for 14 days. On day 11, rats were injected with either 5-Fu or its vehicle. Total blood cells counts and pathological analyses were conducted. Results. ARE enhanced the growth inhibition by 5-Fu in colon cancer cell lines, but almost had no effect on normal colon cells. 5-Fu had serious side effects on the rats. Dietary ARE partially reduced the gastrointestinal damage by 5-Fu. Further studies with advanced tumor models are needed to assess effect of ARE on 5-Fu tumor inhibition in vivo .

ISBN: 9780542476976Subjects--Topical Terms:

1017813
Agriculture, Food Science and Technology.

Effect of anthocyanin-rich extracts on 5-flurouracil chemotherapy.
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035 $a (UnM)AAI1431592
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100 1 $a Su, Ye. $3 1915282
245 1 0 $a Effect of anthocyanin-rich extracts on 5-flurouracil chemotherapy.
300 $a 101 p.
500 $a Source: Masters Abstracts International, Volume: 44-04, page: 1718.
500 $a Chair: Bernadene A. Magnuson.
502 $a Thesis (M.S.)--University of Maryland, College Park, 2006.
520 $a Anthocyanins are natural colorants, with potential chemopreventive activity. 5-Flurouracil (5-Fu) is a widely used cancer chemotherapeutic drug. However, it has serious side effects. Objective. To determine whether anthocyanin-rich-extracts (ARE) can increase the effectiveness of 5-Fu. Methods. Colon cancer cells were treated with ARE in combination with 5-Fu to assess in vitro whether ARE would enhance 5-Fu cytotoxicity. In vivo, rats were given diets with or without ARE for 14 days. On day 11, rats were injected with either 5-Fu or its vehicle. Total blood cells counts and pathological analyses were conducted. Results. ARE enhanced the growth inhibition by 5-Fu in colon cancer cell lines, but almost had no effect on normal colon cells. 5-Fu had serious side effects on the rats. Dietary ARE partially reduced the gastrointestinal damage by 5-Fu. Further studies with advanced tumor models are needed to assess effect of ARE on 5-Fu tumor inhibition in vivo .
590 $a School code: 0117.
650 4 $a Agriculture, Food Science and Technology. $3 1017813
690 $a 0359
710 2 0 $a University of Maryland, College Park. $3 657686
773 0 $t Masters Abstracts International $g 44-04.
790 1 0 $a Magnuson, Bernadene A., $e advisor
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791 $a M.S.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1431592