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The origin and evolution of gonadotr...

Powell, James Frederick Francis.

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The origin and evolution of gonadotropin-releasing hormone in boney fishes.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The origin and evolution of gonadotropin-releasing hormone in boney fishes./
Author:	Powell, James Frederick Francis.
Description:	270 p.
Notes:	Source: Dissertation Abstracts International, Volume: 57-04, Section: B, page: 2391.
Contained By:	Dissertation Abstracts International57-04B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NN08322
ISBN:	9780612083226

The origin and evolution of gonadotropin-releasing hormone in boney fishes.
Powell, James Frederick Francis.

The origin and evolution of gonadotropin-releasing hormone in boney fishes. - 270 p.

Source: Dissertation Abstracts International, Volume: 57-04, Section: B, page: 2391.

Thesis (Ph.D.)--University of Victoria (Canada), 1995.

Gonadotropin-releasing hormone (GnRH) is a decapeptide with a central role in vertebrate reproduction. Each of the GnRH peptides characterized by primary structure has a modified pyroglutamyl N-terminus and conserved amino acids in positions 1, 2, 4, 9 and 10. GnRH peptides belong to a family, but not a superfamily, of related peptides. The evolutionary changes in this neuropeptide family are examined in regard to structure and role in reproduction.

ISBN: 9780612083226Subjects--Topical Terms:

1017680
Biology, Neuroscience.

The origin and evolution of gonadotropin-releasing hormone in boney fishes.
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020 $a 9780612083226
035 $a (UnM)AAINN08322
035 $a AAINN08322
040 $a UnM $c UnM
100 1 $a Powell, James Frederick Francis. $3 1914682
245 1 4 $a The origin and evolution of gonadotropin-releasing hormone in boney fishes.
300 $a 270 p.
500 $a Source: Dissertation Abstracts International, Volume: 57-04, Section: B, page: 2391.
500 $a Adviser: N. M. Sherwood.
502 $a Thesis (Ph.D.)--University of Victoria (Canada), 1995.
520 $a Gonadotropin-releasing hormone (GnRH) is a decapeptide with a central role in vertebrate reproduction. Each of the GnRH peptides characterized by primary structure has a modified pyroglutamyl N-terminus and conserved amino acids in positions 1, 2, 4, 9 and 10. GnRH peptides belong to a family, but not a superfamily, of related peptides. The evolutionary changes in this neuropeptide family are examined in regard to structure and role in reproduction.
520 $a The primary structure of GnRH peptides from nervous tissue of boney fishes and a tunicate was determined by using high performance liquid chromatography (HPLC), radioimmunoassay (RIA) and sequence analysis. In addition, indirect investigations using HPLC and RIA were used to help delineate the evolution of GnRH.
520 $a In this thesis, mammalian GnRH (mGnRH) is characterized by primary structure from a living representative of an ancient boney fish, the Russian sturgeon Acipenser gueldenstaedti. As well, mGnRH is shown to be present in the brains of early-evolved teleosts such as the butterflyfish (Pantadon bucholzi), a boney tongued fish in the order Osteoglossiformes and the moray eel (Muraena militaris) in the order Anguilliformes. In the herring (Clupea harengus pallasi), three forms of GnRH are present in the brain: salmon GnRH (sGnRH), chicken GnRH-II (cGnRH-II) and a novel form, herring GnRH (hGnRH). Herring represent the most phylogenetically ancient fish with sGnRH as confirmed by primary structure, although evidence is presented that the knifefish, Xenomystus nigri, (Osteoglossiformes) may also have sGnRH in their brains. As well, mGnRH disappears in early-evolved teleosts such as herring and knifefish. The identification of hGnRH by primary structure represents the first known appearance of three forms of GnRH within a species.
520 $a The presence of sGnRH and cGnRH-II in salmon was confirmed by primary structure. As well, the distribution of these two forms was shown to include eight other species of salmonids from three genera. The physiological role of GnRH was investigated in chinook salmon (Oncorhynchus tshawytcha) by measuring plasma gonadotropin levels in fish induced to ovulate by exogenous application of a sGnRH analogue. The sGnRH analogue induced ovulation by increasing plasma gonadotropin-II levels concommitant with decreasing plasma gonadotropin-I levels.
520 $a The primary structure of a novel form of GnRH, sea bream GnRH (sbCnRH), is identified in fishes of the order Perciformes: the sea bream (Sparus aurata), tilapia (Oreochromis niloticus) and another cichlid fish, Haplochromis burtoni. In addition, sGnRH for tilapia and cGnRH-II for sea bream and tilapia are characterized by primary structure. An abundance of sbGnRH in the pituitary of percomorph fishes supports the role of sbGnRH as the physiological releaser of the gonadotropins. The phylogenetic origin of sbGnRH was traced using HPLC and RIA to the rockfish (Sebastes rastelliger; Scorpaeniformes).
520 $a The invertebrate origin of GnRH is shown by the identification of two novel forms of GnRH by primary structure in the tunicate, Chelyosoma productum. Tunicate GnRH-I is related to the ancestral lamprey GnRH-III by its structure and a putative salt bridge between residues 5 and 8. Tunicate GnRH-II contains a cysteine residue in position 6 and appears to be a homodimer. The identification of two GnRH peptides in tunicates represents a conservation of GnRH that spans 600 million years.
590 $a School code: 0244.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Zoology. $3 1018632
650 4 $a Biology, Animal Physiology. $3 1017835
690 $a 0317
690 $a 0472
690 $a 0433
710 2 0 $a University of Victoria (Canada). $3 1019404
773 0 $t Dissertation Abstracts International $g 57-04B.
790 1 0 $a Sherwood, N. M., $e advisor
790 $a 0244
791 $a Ph.D.
792 $a 1995
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NN08322