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Target genes of LIN-12/Notch signali...

Yoo, Andrew S.

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Target genes of LIN-12/Notch signaling in vulval precursor cells in Caenorhabditis elegans.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Target genes of LIN-12/Notch signaling in vulval precursor cells in Caenorhabditis elegans./
作者:	Yoo, Andrew S.
面頁冊數:	143 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6404.
Contained By:	Dissertation Abstracts International66-12B.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3199597
ISBN:	9780542463839

Target genes of LIN-12/Notch signaling in vulval precursor cells in Caenorhabditis elegans.
Yoo, Andrew S.

Target genes of LIN-12/Notch signaling in vulval precursor cells in Caenorhabditis elegans. - 143 p.

Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6404.

Thesis (Ph.D.)--Columbia University, 2006.

The C. elegans vulva is an important paradigm for cell-cell interactions in animal development. The fates of six vulval precursor cells are patterned through the action of the EGFR-MAPK inductive signaling pathway, which specifies the "1°" fate, and the LIN-12/Notch lateral signaling pathway, which specifies the "2°" fate.

ISBN: 9780542463839Subjects--Topical Terms:

1017730
Biology, Genetics.

Target genes of LIN-12/Notch signaling in vulval precursor cells in Caenorhabditis elegans.
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500 $a Adviser: Iva Greenwald.
502 $a Thesis (Ph.D.)--Columbia University, 2006.
520 $a The C. elegans vulva is an important paradigm for cell-cell interactions in animal development. The fates of six vulval precursor cells are patterned through the action of the EGFR-MAPK inductive signaling pathway, which specifies the "1°" fate, and the LIN-12/Notch lateral signaling pathway, which specifies the "2°" fate.
520 $a We provide evidence that the inductive signal is spatially graded and initially activates the EGFR-MAPK pathway in the prospective 2° cells. Subsequently, this effect is counteracted by the expression of multiple new negative regulators of the EGFR-MAPK pathway, under direct transcriptional control of the LIN-12-mediated lateral signal.
520 $a We also identify a microRNA gene, mir-61, as a direct transcriptional target of LIN-12, and show that expression of mir-61 promotes the 2° fate. We identify vav-1, the ortholog of the Vav oncogene, as a target of mir-61, and show that downregulation of VAV-1 promotes lin-12 activity in specifying the 2° fate. Our results suggest that lin-12, mir-61 and vav-1 form a feedback loop that helps maximize lin-12 activity in the presumptive 2° VPCs.
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