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Pseudomonas aeruginosa biofilms as a...

Landry, Rebecca Marie.

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Pseudomonas aeruginosa biofilms as an important host-pathogen relationship in cystic fibrosis: Design and implementation of biorelevant surfaces in the study of disease.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Pseudomonas aeruginosa biofilms as an important host-pathogen relationship in cystic fibrosis: Design and implementation of biorelevant surfaces in the study of disease./
作者:	Landry, Rebecca Marie.
面頁冊數:	100 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3126.
Contained By:	Dissertation Abstracts International66-06B.
標題:	Chemistry, Inorganic. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3177756
ISBN:	9780542173455

Pseudomonas aeruginosa biofilms as an important host-pathogen relationship in cystic fibrosis: Design and implementation of biorelevant surfaces in the study of disease.
Landry, Rebecca Marie.

Pseudomonas aeruginosa biofilms as an important host-pathogen relationship in cystic fibrosis: Design and implementation of biorelevant surfaces in the study of disease. - 100 p.

Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3126.

Thesis (Ph.D.)--Northwestern University, 2005.

In the genetic disease cystic fibrosis (CF), the compromised patient typically succumbs to chronic infection and the resultant severe lung damage brought about by the opportunistic pathogen, Pseudomonas aeruginosa . In CF airways, P. aeruginosa forms surface-associated communities called biofilms which are implicated in the pathogenesis of the disease. Research suggests therapeutic strategies directed toward biofilms may be successful in treating CF lung infections. However, scientists are limited to the model systems in which they study biofilm formation in the CF lung. A more representative model of in vivo bacterial growth is presented in this thesis. The work presented in this thesis utilizes well-established self-assembly surface chemistry to investigate different properties of P. aeruginosa biofilm development related to CF.

ISBN: 9780542173455Subjects--Topical Terms:

517253
Chemistry, Inorganic.

Pseudomonas aeruginosa biofilms as an important host-pathogen relationship in cystic fibrosis: Design and implementation of biorelevant surfaces in the study of disease.
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245 1 0 $a Pseudomonas aeruginosa biofilms as an important host-pathogen relationship in cystic fibrosis: Design and implementation of biorelevant surfaces in the study of disease.
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500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3126.
500 $a Adviser: Joseph T. Hupp.
502 $a Thesis (Ph.D.)--Northwestern University, 2005.
520 $a In the genetic disease cystic fibrosis (CF), the compromised patient typically succumbs to chronic infection and the resultant severe lung damage brought about by the opportunistic pathogen, Pseudomonas aeruginosa . In CF airways, P. aeruginosa forms surface-associated communities called biofilms which are implicated in the pathogenesis of the disease. Research suggests therapeutic strategies directed toward biofilms may be successful in treating CF lung infections. However, scientists are limited to the model systems in which they study biofilm formation in the CF lung. A more representative model of in vivo bacterial growth is presented in this thesis. The work presented in this thesis utilizes well-established self-assembly surface chemistry to investigate different properties of P. aeruginosa biofilm development related to CF.
520 $a Chapter 2 describes the development of a technique to derivatize surfaces with molecules that are abundant in CF airways in order to investigate their impact on P. aeruginosa biofilm development. Biofilms formed on mucin-coated surfaces develop large cellular aggregates and exhibit increased tolerance to the antibiotic tobramycin compared to biofilms grown on glass. These experiments suggest that mucin, which serves as an attachment surface in CF airways, profoundly impacts P. aeruginosa biofilm development and function.
520 $a Chapter 3 engages in the scientific debate on specific pseudomonal receptors present in CF airways. This chapter details a new approach for studying bacterial attachment and subsequent biofilm development on lipid membranes as biomimetic substrates. Both the asialoGM1 ligand, which is found in increased quantities on CF epithelial surfaces, and the CFTR first extracellular binding domains are effective receptors for immobilizing P. aeruginosa.
520 $a Chapter 4 describes the first example of an inhibitory surface against P. aeruginosa. This chapter describes the use of titanium (IV) dioxide nanoporous films to continuously inhibit P. aeruginosa attachment and growth. This highly effective inhibitory surface offers potential applications for patterning P. aeruginosa in order to study quorum sensing.
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