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The effect of protein and specific a...

Heck, Julia Elizabeth.

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The effect of protein and specific amino acids on arsenic-related health effects in Bangladesh.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The effect of protein and specific amino acids on arsenic-related health effects in Bangladesh./
作者:	Heck, Julia Elizabeth.
面頁冊數:	186 p.
附註:	Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 1949.
Contained By:	Dissertation Abstracts International67-04B.
標題:	Health Sciences, Public Health. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3213517
ISBN:	9780542637575

The effect of protein and specific amino acids on arsenic-related health effects in Bangladesh.
Heck, Julia Elizabeth.

The effect of protein and specific amino acids on arsenic-related health effects in Bangladesh. - 186 p.

Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 1949.

Thesis (Ph.D.)--Columbia University, 2006.

Background. Millions worldwide are being exposed to arsenic through drinking water, which is associated with increased risks of skin cancer. Results from experimental research have found that dietary protein and specific amino acids may assist with arsenic methylation and consequently decrease disease risk. The purpose of this dissertation was to examine intakes of protein, methionine, and cysteine and to examine their association with total urinary arsenic excretion and risk of prevalent skin lesions.

ISBN: 9780542637575Subjects--Topical Terms:

1017659
Health Sciences, Public Health.

The effect of protein and specific amino acids on arsenic-related health effects in Bangladesh.
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100 1 $a Heck, Julia Elizabeth. $3 1914120
245 1 4 $a The effect of protein and specific amino acids on arsenic-related health effects in Bangladesh.
300 $a 186 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 1949.
500 $a Adviser: Habibul Ahsan.
502 $a Thesis (Ph.D.)--Columbia University, 2006.
520 $a Background. Millions worldwide are being exposed to arsenic through drinking water, which is associated with increased risks of skin cancer. Results from experimental research have found that dietary protein and specific amino acids may assist with arsenic methylation and consequently decrease disease risk. The purpose of this dissertation was to examine intakes of protein, methionine, and cysteine and to examine their association with total urinary arsenic excretion and risk of prevalent skin lesions.
520 $a Methods. Subjects were 11,170 participants in the Health Effects of Arsenic Longitudinal Study (HEALS), a prospective cohort study established in Araihazar, Bangladesh in 2000. Trained personnel conducted standardized interviews with all subjects. Diet was assessed by a food frequency questionnaire designed for the study and nutrient composition was taken from the USDA National Nutrient Database for Standard Reference. Study physicians clinically examined subjects to determine the presence of skin lesions and collected urine samples. Generalized estimating equations were used to examine the association of intakes of protein, methionine, and cysteine with urinary arsenic and skin lesions. Analyses controlled for arsenic exposure, age, sex, occupation, smoking, and other nutrients.
520 $a Results. Average caloric intake was 2142 and 2394 kcal/day among women and men, respectively, while mean protein intakes were 67.5 and 78.2 g/day. Methionine intake averaged 1.61 gm/day, while cysteine intake averaged 0.87 g/day. Those at the highest quintiles of protein, methionine, and cysteine had the highest urinary arsenic excretion, after controlling for arsenic exposure and other predictors. There were significantly greater odds ratios (OR) for skin lesions among those at the lowest quintile of methionine (adjusted OR=1.35, 95% CI: 1.08-1.69) and cysteine (adjusted OR=1.26, 95% CI: 1.01-1.57) intakes. Women at the lowest quintile of methionine intake (adjusted OR=2.13, 95% CI: 1.13-4.00) had a greater risk of skin lesions than men (adjusted OR=1.16, 95% CI: 0.91-1.49).
520 $a Conclusions. Our results support a protective role for protein and specific amino acids in mitigating the health effects of arsenic exposure. In conjunction with experimental evidence supporting their role in arsenic methylation, this dissertation suggests there may be a potentially beneficial effect of supplementation with amino acids among arsenic-exposed populations.
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