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Neuronal correlates of somatosensori...

Sandler, Aaron James.

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Neuronal correlates of somatosensorimotor learning and decision making in primates.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Neuronal correlates of somatosensorimotor learning and decision making in primates./
Author:	Sandler, Aaron James.
Description:	175 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2992.
Contained By:	Dissertation Abstracts International66-06B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3181506
ISBN:	9780542210709

Neuronal correlates of somatosensorimotor learning and decision making in primates.
Sandler, Aaron James.

Neuronal correlates of somatosensorimotor learning and decision making in primates. - 175 p.

Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2992.

Thesis (Ph.D.)--Duke University, 2005.

Making appropriate responses to sensory cues is fundamental for animal survival. Current evidence suggests that primate decision-making based on sensory cues involves multiple subcortical and cortical structures, including areas of cortex traditionally thought to be primarily sensory, motor, or associative. Little is known, however, about the neuronal processes that underlie decision-making based on somatosensory cues, or about the electrophysiological changes that occur over the course of learning to associate those somatosensory cues with motor responses.

ISBN: 9780542210709Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Neuronal correlates of somatosensorimotor learning and decision making in primates.
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100 1 $a Sandler, Aaron James. $3 1914084
245 1 0 $a Neuronal correlates of somatosensorimotor learning and decision making in primates.
300 $a 175 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2992.
500 $a Supervisor: Miguel A. L. Nicolelis.
502 $a Thesis (Ph.D.)--Duke University, 2005.
520 $a Making appropriate responses to sensory cues is fundamental for animal survival. Current evidence suggests that primate decision-making based on sensory cues involves multiple subcortical and cortical structures, including areas of cortex traditionally thought to be primarily sensory, motor, or associative. Little is known, however, about the neuronal processes that underlie decision-making based on somatosensory cues, or about the electrophysiological changes that occur over the course of learning to associate those somatosensory cues with motor responses.
520 $a We addressed this by recording chronic, simultaneous, extracellular firing activity from many neuronal units in multiple cortical areas of two owl monkeys (Aotus trivirgatus) during somatosensorimotor learning and then, once the task was learned, while the monkey made decisions based on somatosensory cues. The areas studied were primary somatosensory (S1), posterior parietal (PPC), dorsal premotor (PMd), and primary motor (M1) cortices. The task required the monkeys to associate each of two spatially distinct vibrotactile stimuli with a specific reach target in order to obtain a food reward.
520 $a In the learning experiment, we found that improvement in task performance was accompanied by changes in neuronal activity in all of the cortical areas studied. Specifically, information about reach direction was present several seconds before the initiation of reach, and this information appeared progressively earlier and reached an increasingly higher level over the course of learning, indicating that a very widely distributed cortical network is involved in primate somatosensorimotor learning.
520 $a In the decision-making experiment, we used within-session reversals to dissociate stimulus-related, reach-related, and hybrid stimulus/reach neuronal activity. We found that all four areas each contained all three types of units. Most tuned S1 units (63% of tuned units) encoded for stimulus, while the majority of tuned units in PPC (70%), PMd (64%), and M1 (67%) encoded for reach. Despite these differences, hybrid stimulus/reach units were found in all areas studied, indicating the existence of a widespread network for somatosensorimotor decision-making. Furthermore, most units classified as stimulus- or reach-related also showed some degree of tuning for the other variable, suggesting that there may be no clear distinctions between neurons that encode for somatosensation, decision-making, and motor execution.
520 $a These findings contradict classical feedforward theories of cortical function, suggesting instead that a widely distributed cortical network is involved in all aspects of somatosensorimotor learning and decision-making.
590 $a School code: 0066.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Zoology. $3 1018632
690 $a 0317
690 $a 0472
710 2 0 $a Duke University. $3 569686
773 0 $t Dissertation Abstracts International $g 66-06B.
790 1 0 $a Nicolelis, Miguel A. L., $e advisor
790 $a 0066
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3181506