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beta-carotene bioefficacy and preven...

Zhu, Dongwei.

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beta-carotene bioefficacy and prevention of lipid peroxidation by lycopene.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	beta-carotene bioefficacy and prevention of lipid peroxidation by lycopene./
作者:	Zhu, Dongwei.
面頁冊數:	143 p.
附註:	Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2568.
Contained By:	Dissertation Abstracts International67-05B.
標題:	Chemistry, Pharmaceutical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3218802
ISBN:	9780542701894

beta-carotene bioefficacy and prevention of lipid peroxidation by lycopene.
Zhu, Dongwei.

beta-carotene bioefficacy and prevention of lipid peroxidation by lycopene. - 143 p.

Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2568.

Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2006.

Lipid peroxidation and associated processes have been linked to a series of pathological events, such as atherosclerosis, carcinogenesis, diabetes, and hepatic diseases. Lycopene, a major carotenoid found in tomatoes, can function as an antioxidant to quench singlet oxygen and scavenge peroxyl radicals. Cervical cancer cell culture studies and a prostate cancer clinical trial were undertaken to understand the effects of lycopene in the prevention of lipid peroxidation.

ISBN: 9780542701894Subjects--Topical Terms:

550957
Chemistry, Pharmaceutical.

beta-carotene bioefficacy and prevention of lipid peroxidation by lycopene.
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500 $a Adviser: Richard B. van Breemen.
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520 $a Lipid peroxidation and associated processes have been linked to a series of pathological events, such as atherosclerosis, carcinogenesis, diabetes, and hepatic diseases. Lycopene, a major carotenoid found in tomatoes, can function as an antioxidant to quench singlet oxygen and scavenge peroxyl radicals. Cervical cancer cell culture studies and a prostate cancer clinical trial were undertaken to understand the effects of lycopene in the prevention of lipid peroxidation.
520 $a To evaluate the extent of lipid peroxidation in vivo and in vitro, malondialdehyde (MDA) was selected as a biomarker of lipid peroxidation. Two liquid chromatography tandem mass spectrometry (LC-MS-MS) assays were developed to efficiently quantify MDA as a derivative of diethyl thiobarbituric acid (cervical cancer study) or a thiobartituric acid (prostate cancer study). In the cervical cancer study, a decrease in formation of MDA was observed in cells treated with lycopene. In men with prostate cancer or benign prostate hyperplasia lycopene administered 30 mg/day lycopene for 21 days produced a negative association as measured by the Pearson correlation between MDA variance. This means that as lycopene levels increased as a result of intervention, lipid peroxidation decreased.
520 $a beta-carotene is the most active provitamin A carotenoid. Furthermore, vitamin A deficiency is the major cause of night blindness and childhood mortality in the world. Since the bioefficacy (defined as bioavailability plus bioconversion to retinol) of beta-carotene remains uncertain, a clinical study was carried out to help clarify its bioefficacy based on a plateau isotope enrichment approach using carbon-13 labeled beta-carotene and retinol. To facilitate the measurement labeled beta-carotene in human serum and feces, an existing liquid chromatography-mass spectrometry (LC-MS) assay had to be adapted. Saponification was applied in sample preparation to eliminate the interfering triglycerides or diglycerides in serum samples. Negative ion APCI (Atmosphere Pressure Chemical Ionization) was applied in ionization mode to improve selectivity and sensitivity. Finally, the vitamin A activity of 3.1 mug beta-carotene was found to be equivalent to 1 mug retinol. The bioefficacy of beta-carotene is therefore 31% in oil for the healthy adult.
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