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Factors affecting the regulation of ...

Flory, Graham S.

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Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey./
作者:	Flory, Graham S.
面頁冊數:	126 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 1212.
Contained By:	Dissertation Abstracts International66-02B.
標題:	Psychology, Psychobiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3163796
ISBN:	9780496981151

Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey.
Flory, Graham S.

Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey. - 126 p.

Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 1212.

Thesis (Ph.D.)--University of Michigan, 2005.

It has been suggested that the motivation (of both humans and animals) to self-administer drugs is governed by a homeostatic mechanism that acts to achieve and maintain a constant level of circulating drug in the brain. This notion is both central to a prominent contemporary theory of drug addiction (the "reward-allostasis" model) and has for decades been the source of considerable confusion in the ethanol self-administration literature, as animals invariably self-administer between 300--400% more ethanol by the intravenous route than they do by the oral route.

ISBN: 9780496981151Subjects--Topical Terms:

1017821
Psychology, Psychobiology.

Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey.
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245 1 0 $a Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey.
300 $a 126 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 1212.
500 $a Chairman: James H. Woods.
502 $a Thesis (Ph.D.)--University of Michigan, 2005.
520 $a It has been suggested that the motivation (of both humans and animals) to self-administer drugs is governed by a homeostatic mechanism that acts to achieve and maintain a constant level of circulating drug in the brain. This notion is both central to a prominent contemporary theory of drug addiction (the "reward-allostasis" model) and has for decades been the source of considerable confusion in the ethanol self-administration literature, as animals invariably self-administer between 300--400% more ethanol by the intravenous route than they do by the oral route.
520 $a Data obtained in this thesis demonstrate the existence of a stable ascending limb to the dose-response curve for intravenously self-administered ethanol, cocaine, and dilaudid on a continuous schedule of reinforcement in which increases in response rate result in an increased rate of drug intake. These data make it clear that the attainment and maintenance of a threshold level of drug in the brain is not a necessary component of an animal's motivation to self-administer it. Instead, at the relatively low doses that comprise the ascending limb of this function (which include those used in the oral ethanol self-administration paradigm), an increase in dose is accompanied by an increase in the rate of intake.
520 $a This phenomenon may be due to the fact that with larger doses, a given drug effect can be achieved more rapidly than with smaller doses, and that, at low drug doses, faster rates of drug accumulation may impart a greater degree of reinforcing efficacy. Support for this possibility comes from a finding of this thesis that, with dose held constant, an increase in the rate of intravenous infusion engendered significantly more rapid rates of responding and consequently, more rapid rates of drug intake.
590 $a School code: 0127.
650 4 $a Psychology, Psychobiology. $3 1017821
650 4 $a Psychology, Experimental. $3 517106
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710 2 0 $a University of Michigan. $3 777416
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790 $a 0127
791 $a Ph.D.
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