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Characterization of canine leishmani...

Rosypal, Alexa C.

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Characterization of canine leishmaniasis in the United States: Pathogenesis, immunological responses, and transmission of an American isolate of Leishmania infantum.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Characterization of canine leishmaniasis in the United States: Pathogenesis, immunological responses, and transmission of an American isolate of Leishmania infantum./
作者:	Rosypal, Alexa C.
面頁冊數:	179 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 0757.
Contained By:	Dissertation Abstracts International66-02B.
標題:	Biology, Veterinary Science. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3164178
ISBN:	9780496984008

Characterization of canine leishmaniasis in the United States: Pathogenesis, immunological responses, and transmission of an American isolate of Leishmania infantum.
Rosypal, Alexa C.

Characterization of canine leishmaniasis in the United States: Pathogenesis, immunological responses, and transmission of an American isolate of Leishmania infantum. - 179 p.

Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 0757.

Thesis (Ph.D.)--Virginia Polytechnic Institute and State University, 2005.

Leishmania infantum, an etiologic agent of zoonotic visceral leishmaniasis, has recently emerged in the foxhound population in the United States and parts of Canada. Leishmania infections are usually spread to mammals by infected sand flies, however epidemiological data do not support a role for sand fly transmission in North America. The purpose of this work was to isolate and characterize L. infantum from a naturally infected foxhound from Virginia (LIVT-1 isolate). A mouse model of North American leishmaniasis was developed using immunocompetent and genetically immunodeficient mouse strains infected with LIVT-1 promastigotes by different inoculation routes. The intravenous route of infection was superior to the subcutaneous route for inducing consistent experimental infections and mice lacking interferon gamma, inducible nitric oxide synthase, or B-cells were resistant to clinical disease.

ISBN: 9780496984008Subjects--Topical Terms:

1021733
Biology, Veterinary Science.

Characterization of canine leishmaniasis in the United States: Pathogenesis, immunological responses, and transmission of an American isolate of Leishmania infantum.
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500 $a Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 0757.
500 $a Chairs: David S. Lindsay; Anne M. Zajac.
502 $a Thesis (Ph.D.)--Virginia Polytechnic Institute and State University, 2005.
520 $a Leishmania infantum, an etiologic agent of zoonotic visceral leishmaniasis, has recently emerged in the foxhound population in the United States and parts of Canada. Leishmania infections are usually spread to mammals by infected sand flies, however epidemiological data do not support a role for sand fly transmission in North America. The purpose of this work was to isolate and characterize L. infantum from a naturally infected foxhound from Virginia (LIVT-1 isolate). A mouse model of North American leishmaniasis was developed using immunocompetent and genetically immunodeficient mouse strains infected with LIVT-1 promastigotes by different inoculation routes. The intravenous route of infection was superior to the subcutaneous route for inducing consistent experimental infections and mice lacking interferon gamma, inducible nitric oxide synthase, or B-cells were resistant to clinical disease.
520 $a Experimental infections in dogs were performed to examine the infectivity, immune responses, and pathogenicity of LIVT-1. Experimentally infected dogs developed parasitologically proven infections and a range of clinical manifestations that were similar to those observed in naturally occurring disease. Diagnostic tests including culture and cytologic evaluation of bone marrow and lymph node aspirates, polymerase chain reaction, and serology by indirect fluorescent antibody test, and recombinant K39 (rK39) immunoassay were evaluated. Kappa statistics revealed that PCR had the highest level of agreement with culture and cytology results although the rK39 dipstick assay consistently identified more experimentally infected dogs. Flow cytometry revealed no significant differences (p > 0.05) in CD4+ or CD8+ expression on peripheral blood lymphocytes.
520 $a Alternate transmission mechanisms in experimentally inoculated mice and dogs were investigated. PCR revealed a low level of vertical and direct transmission of LIVT-1 in inoculated BALB/c mice. Leishmania DNA was detectable by PCR in tissues from puppies from a LIVT-1 infected beagle.
520 $a Although the strain of L. infantum infecting foxhounds in North America appears to predominantly use a non-vector transmission mode, the disease it produces is similar to canine leishmaniasis in other parts of the world. Non-sand fly transmission may be responsible for maintaining infections in the foxhound population. Results from this work will lead to improvement in diagnosis, clinical management, and control of canine leishmaniasis in North America.
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