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Anti-egress activity of antibodies p...

Costales, Jaime.

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Anti-egress activity of antibodies present in human chagasic sera and involvement of cruzipain and host cell permeability in the process of Trypanosoma cruzi egress from infected cells.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Anti-egress activity of antibodies present in human chagasic sera and involvement of cruzipain and host cell permeability in the process of Trypanosoma cruzi egress from infected cells./
作者:	Costales, Jaime.
面頁冊數:	158 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 0700.
Contained By:	Dissertation Abstracts International66-02B.
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3162656
ISBN:	9780496966578

Anti-egress activity of antibodies present in human chagasic sera and involvement of cruzipain and host cell permeability in the process of Trypanosoma cruzi egress from infected cells.
Costales, Jaime.

Anti-egress activity of antibodies present in human chagasic sera and involvement of cruzipain and host cell permeability in the process of Trypanosoma cruzi egress from infected cells. - 158 p.

Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 0700.

Thesis (Ph.D.)--Ohio University, 2005.

Antibodies present in the serum of mice experimentally infected with the protozoan parasite Trypanosoma cruzi are capable of blocking the parasite egress from infected cells in vitro. These antibodies, termed antiegressin, have been postulated to work through binding the surface of the infected host cell, thereby preventing parasite egress. This dissertation describes the presence of antibodies in human serum samples from chagasic individuals that present similar anti-egress capabilities. Human sera samples were collected in regions of Ecuador endemic for T. cruzi infection, and samples from nine individuals that were serologically characterized as chagasic showed egress-inhibiting capabilities, while samples from serologically negative individuals did not.

ISBN: 9780496966578Subjects--Topical Terms:

1017734
Biology, Microbiology.

Anti-egress activity of antibodies present in human chagasic sera and involvement of cruzipain and host cell permeability in the process of Trypanosoma cruzi egress from infected cells.
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245 1 0 $a Anti-egress activity of antibodies present in human chagasic sera and involvement of cruzipain and host cell permeability in the process of Trypanosoma cruzi egress from infected cells.
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500 $a Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 0700.
500 $a Director: Edwin C. Rowland.
502 $a Thesis (Ph.D.)--Ohio University, 2005.
520 $a Antibodies present in the serum of mice experimentally infected with the protozoan parasite Trypanosoma cruzi are capable of blocking the parasite egress from infected cells in vitro. These antibodies, termed antiegressin, have been postulated to work through binding the surface of the infected host cell, thereby preventing parasite egress. This dissertation describes the presence of antibodies in human serum samples from chagasic individuals that present similar anti-egress capabilities. Human sera samples were collected in regions of Ecuador endemic for T. cruzi infection, and samples from nine individuals that were serologically characterized as chagasic showed egress-inhibiting capabilities, while samples from serologically negative individuals did not.
520 $a Furthermore, evidence provided here shows that proteins located at the surface of infected BALB/c fibroblasts in vitro are in fact bound by antibodies present in the sera of experimentally infected mice. One of these proteins was purified by immunoprecipitation and identified as a 98 kDa peptide and, through amino acid sequencing by mass spectrometry, shown to contain the serine protease inhibitor alpha-1-antitrypsin.
520 $a The process of T. cruzi egress was also further characterized by using specific inhibitors of the major cysteine protease from T. cruzi, cruzipain, which was shown to be involved in the process of egress from infected cells. Furthermore, plasma membrane integrity tests demonstrated that infection induced permeabilization of BALB/c cells starting three days after the infection by T. cruzi. The possibility that antibodies with antiegress activity are capable of entering the host cell due to this permeabilization event was also studied, and evidence is provided suggesting this possibility.
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