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Theoretical and functional character...

Vago, David R.

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Theoretical and functional characterization of the direct cortical input into the CA1 subregion of the hippocampus: Behavioral modulation of the temporoammonic pathway by a nonselective dopamine agonist.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Theoretical and functional characterization of the direct cortical input into the CA1 subregion of the hippocampus: Behavioral modulation of the temporoammonic pathway by a nonselective dopamine agonist./
作者:	Vago, David R.
面頁冊數:	151 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 6327.
Contained By:	Dissertation Abstracts International66-11B.
標題:	Psychology, Physiological. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3194806
ISBN:	9780542397806

Theoretical and functional characterization of the direct cortical input into the CA1 subregion of the hippocampus: Behavioral modulation of the temporoammonic pathway by a nonselective dopamine agonist.
Vago, David R.

Theoretical and functional characterization of the direct cortical input into the CA1 subregion of the hippocampus: Behavioral modulation of the temporoammonic pathway by a nonselective dopamine agonist. - 151 p.

Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 6327.

Thesis (Ph.D.)--The University of Utah, 2005.

The CA1 subregion of the hippocampus receives cortical information by two distinct pathways: (a) directly form entorhinal cortex (EC) via the perforant path (pp) projection (Temporammonic pathway [TA]) and (b) indirectly via the trisynaptic circuit. The indirect path has been studied quite extensively; however, the direct path has only recently been characterized electrophysiologically and neurochemically. It was recently shown that dopamine selectively inhibits the pp projection to CA1 while having little to no effect on the input coming from CA3 (via the trisynaptic circuit). Neurodegeneration of these pathways into the hippocampus has been associated with impairments in Alzheimer's disease, epilepsy, and ischemic or anoxic episodes, whereas hyperactive dopaminergic systems (e.g. schizophrenia, Attention Deficit Hyperactivity Disorder) have been associated with sensory gating-, attention-, and memory-related deficits. With the current understanding of hippocampal circuitry, one may speculate that pathological hyperactivity of dopaminergic systems isolates the CA1 region from receiving any specific sensory information and thus causes abnormalities in processing information. Such deficits may manifest themselves in learning and memory tasks. To date, the behavioral implications in such deficits parallel an incomplete understanding of the importance of the TA pathway and its differentiation from the trisynaptic circuitry in specific learning and memory paradigms. The primary aim of this dissertation was to use dopamine as a tool to assess the behavioral role of the TA pathway with CA1-dependent learning and memory tasks. We hypothesized that the direct cortical input is functionally important in CA1-specific, but not CA3-specific, learning and memory tasks.

ISBN: 9780542397806Subjects--Topical Terms:

1017869
Psychology, Physiological.

Theoretical and functional characterization of the direct cortical input into the CA1 subregion of the hippocampus: Behavioral modulation of the temporoammonic pathway by a nonselective dopamine agonist.
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245 1 0 $a Theoretical and functional characterization of the direct cortical input into the CA1 subregion of the hippocampus: Behavioral modulation of the temporoammonic pathway by a nonselective dopamine agonist.
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500 $a Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 6327.
500 $a Adviser: Raymond P. Kesner.
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520 $a The CA1 subregion of the hippocampus receives cortical information by two distinct pathways: (a) directly form entorhinal cortex (EC) via the perforant path (pp) projection (Temporammonic pathway [TA]) and (b) indirectly via the trisynaptic circuit. The indirect path has been studied quite extensively; however, the direct path has only recently been characterized electrophysiologically and neurochemically. It was recently shown that dopamine selectively inhibits the pp projection to CA1 while having little to no effect on the input coming from CA3 (via the trisynaptic circuit). Neurodegeneration of these pathways into the hippocampus has been associated with impairments in Alzheimer's disease, epilepsy, and ischemic or anoxic episodes, whereas hyperactive dopaminergic systems (e.g. schizophrenia, Attention Deficit Hyperactivity Disorder) have been associated with sensory gating-, attention-, and memory-related deficits. With the current understanding of hippocampal circuitry, one may speculate that pathological hyperactivity of dopaminergic systems isolates the CA1 region from receiving any specific sensory information and thus causes abnormalities in processing information. Such deficits may manifest themselves in learning and memory tasks. To date, the behavioral implications in such deficits parallel an incomplete understanding of the importance of the TA pathway and its differentiation from the trisynaptic circuitry in specific learning and memory paradigms. The primary aim of this dissertation was to use dopamine as a tool to assess the behavioral role of the TA pathway with CA1-dependent learning and memory tasks. We hypothesized that the direct cortical input is functionally important in CA1-specific, but not CA3-specific, learning and memory tasks.
520 $a This dissertation consists of a theoretical model of dopamine modulation in mesocortcicolimbic circuitry and a series of four behavioral experiments that utilized a model of dopaminergic modulation to selectively disrupt the TA pathway and assess its contribution to the CA1 subregion in terms of (a) intermediate-term working memory, (b) transfer of rule-based information, (c) general maze learning, (d) short-term encoding of spatial and contextual information, (e) intermediate-term retrieval of spatial, contextual, and cue-associated information, and finally (f) match-mismatch/novelty detection for objects and spatial information. Our results generally indicate that the TA pathway plays an important modulatory role in many forms of memory processing that has previously been implicated in CA1-, but not CA3-, dependent functioning. The results further suggest a more fundamental role for EC---CA1 synaptic transmission.
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