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Developing mouse models to understan...

Clevenger, Amy Christine.

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Developing mouse models to understand olfactory deficits in schizophrenia.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Developing mouse models to understand olfactory deficits in schizophrenia./
作者:	Clevenger, Amy Christine.
面頁冊數:	171 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-07, Section: B, page: 3569.
Contained By:	Dissertation Abstracts International66-07B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3182042
ISBN:	9780542227974

Developing mouse models to understand olfactory deficits in schizophrenia.
Clevenger, Amy Christine.

Developing mouse models to understand olfactory deficits in schizophrenia. - 171 p.

Source: Dissertation Abstracts International, Volume: 66-07, Section: B, page: 3569.

Thesis (Ph.D.)--University of Colorado Health Sciences Center, 2005.

Schizophrenia is a complex disorder that likely involves multiple pathological processes. Because many of its symptoms are uniquely human, such as paranoia and difficulty with interpersonal relationships, the development of animal models has been extremely limited. Since a subset of schizophrenic individuals suffers from problems with olfaction, understanding the etiology of olfactory symptoms could provide insights into similar pathological processes occurring elsewhere in the central nervous system of these patients. In addition, many of the protein expression changes identified in schizophrenia occur in other diseases, such as Alzheimer's and Parkinson's diseases. Understanding olfactory dysfunction in light of these protein expression changes could help us understand olfactory deficits associated with multiple disease processes. Therefore, the research presented here focuses on the development and analysis of animal models of schizophrenia as they relate to olfaction. We describe a technique which can be utilized for the fast and accurate assessment of olfactory detection threshold in mice. In addition, we discuss the progress we have made toward understanding olfactory function in relation to two pathophysiologic hypotheses of schizophrenia: the neurotrophic and cholinergic hypotheses. Specifically, we describe the expression patterns of brain derived neurotrophic factor and the alpha7-nicotinic acetylcholine receptor in the adult mouse olfactory epithelium and bulb, and we begin to correlate alpha7 expression with olfactory discrimination behavior in mice. Finally, we discuss work that is currently ongoing or planned by the laboratory to expand on the understanding of these two proteins in relation to olfactory function, as well as future work to explore other neurotransmitter systems altered in schizophrenia.

ISBN: 9780542227974Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Developing mouse models to understand olfactory deficits in schizophrenia.
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520 $a Schizophrenia is a complex disorder that likely involves multiple pathological processes. Because many of its symptoms are uniquely human, such as paranoia and difficulty with interpersonal relationships, the development of animal models has been extremely limited. Since a subset of schizophrenic individuals suffers from problems with olfaction, understanding the etiology of olfactory symptoms could provide insights into similar pathological processes occurring elsewhere in the central nervous system of these patients. In addition, many of the protein expression changes identified in schizophrenia occur in other diseases, such as Alzheimer's and Parkinson's diseases. Understanding olfactory dysfunction in light of these protein expression changes could help us understand olfactory deficits associated with multiple disease processes. Therefore, the research presented here focuses on the development and analysis of animal models of schizophrenia as they relate to olfaction. We describe a technique which can be utilized for the fast and accurate assessment of olfactory detection threshold in mice. In addition, we discuss the progress we have made toward understanding olfactory function in relation to two pathophysiologic hypotheses of schizophrenia: the neurotrophic and cholinergic hypotheses. Specifically, we describe the expression patterns of brain derived neurotrophic factor and the alpha7-nicotinic acetylcholine receptor in the adult mouse olfactory epithelium and bulb, and we begin to correlate alpha7 expression with olfactory discrimination behavior in mice. Finally, we discuss work that is currently ongoing or planned by the laboratory to expand on the understanding of these two proteins in relation to olfactory function, as well as future work to explore other neurotransmitter systems altered in schizophrenia.
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