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Dopamine related temporal processing...

Nili, Michael Anthony.

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Dopamine related temporal processing errors in prenatally stressed rats.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Dopamine related temporal processing errors in prenatally stressed rats./
Author:	Nili, Michael Anthony.
Description:	80 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2990.
Contained By:	Dissertation Abstracts International66-06B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3180473
ISBN:	9780542205958

Dopamine related temporal processing errors in prenatally stressed rats.
Nili, Michael Anthony.

Dopamine related temporal processing errors in prenatally stressed rats. - 80 p.

Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2990.

Thesis (Ph.D.)--University of Southern California, 2005.

The data presented in this dissertation address dopamine-related neurodevelopmental impacts of prenatal stress on temporal processing. Pregnant Sprague-Dawley rats were stressed during gestational days 11--14 using 90 seconds of immobilization per day. Their male pups were raised to early adulthood and tested using the Peak Interval (PI) procedure. Using food reward, animals were trained to respond after a 9-second white noise signal (80dB). After the reinforcement training period, though the reward was removed and signal duration increased to 20-seconds, animals continued to show an increased peak response at approximately the expressed time of reinforcement (9s). After training was completed, animals were administered amphetamine (1.2, 2.4, 3.6 mg/kg, s.c.) and haloperidol (0.1, 0.5, 0.9 mg/kg, s.c.) using a crossover design. Animals were retested using the PI procedure and the results were compared with age-matched male rats reared from unstressed mothers. All animals demonstrated a shift towards shorter times with the administration of amphetamine and a shift towards longer times with the administration of haloperidol. Increase in dosage of either drug was coupled with greater peak shifting in the respective direction. No significant differences were observed between prenatally stressed and control animals in peak response time or drug-induced peak shifting. These results imply that the prenatal stress treatment did not impact the learning of intervals of time and temporal memory was functional. However, further analysis demonstrated that prenatal stress significantly increased the number of responses per trial and increased variability in response times. Prenatally stressed animals responded similar to amphetaminized (2.4 mg/kg) control animals. The administration of haloperidol (0.5 mg/kg) led to normalization of their responses, showing significant similarities to control animals under vehicle treatments. These data suggest that the prenatal stress delivered during mid-pregnancy interfered with the normal development of the dopaminergic system of the fetus leading to temporal processing disruptions in the offspring. These results have important clinical significance which could lead to more effective diagnosis and treatment of mental disorders which show temporal disruptions. In addition, the employment of temporal task tests in the clinical setting will introduce another layer of objective assessment which may serve as a vital diagnostic tool.

ISBN: 9780542205958Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Dopamine related temporal processing errors in prenatally stressed rats.
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100 1 $a Nili, Michael Anthony. $3 1912815
245 1 0 $a Dopamine related temporal processing errors in prenatally stressed rats.
300 $a 80 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2990.
500 $a Adviser: William O. McClure.
502 $a Thesis (Ph.D.)--University of Southern California, 2005.
520 $a The data presented in this dissertation address dopamine-related neurodevelopmental impacts of prenatal stress on temporal processing. Pregnant Sprague-Dawley rats were stressed during gestational days 11--14 using 90 seconds of immobilization per day. Their male pups were raised to early adulthood and tested using the Peak Interval (PI) procedure. Using food reward, animals were trained to respond after a 9-second white noise signal (80dB). After the reinforcement training period, though the reward was removed and signal duration increased to 20-seconds, animals continued to show an increased peak response at approximately the expressed time of reinforcement (9s). After training was completed, animals were administered amphetamine (1.2, 2.4, 3.6 mg/kg, s.c.) and haloperidol (0.1, 0.5, 0.9 mg/kg, s.c.) using a crossover design. Animals were retested using the PI procedure and the results were compared with age-matched male rats reared from unstressed mothers. All animals demonstrated a shift towards shorter times with the administration of amphetamine and a shift towards longer times with the administration of haloperidol. Increase in dosage of either drug was coupled with greater peak shifting in the respective direction. No significant differences were observed between prenatally stressed and control animals in peak response time or drug-induced peak shifting. These results imply that the prenatal stress treatment did not impact the learning of intervals of time and temporal memory was functional. However, further analysis demonstrated that prenatal stress significantly increased the number of responses per trial and increased variability in response times. Prenatally stressed animals responded similar to amphetaminized (2.4 mg/kg) control animals. The administration of haloperidol (0.5 mg/kg) led to normalization of their responses, showing significant similarities to control animals under vehicle treatments. These data suggest that the prenatal stress delivered during mid-pregnancy interfered with the normal development of the dopaminergic system of the fetus leading to temporal processing disruptions in the offspring. These results have important clinical significance which could lead to more effective diagnosis and treatment of mental disorders which show temporal disruptions. In addition, the employment of temporal task tests in the clinical setting will introduce another layer of objective assessment which may serve as a vital diagnostic tool.
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710 2 0 $a University of Southern California. $3 700129
773 0 $t Dissertation Abstracts International $g 66-06B.
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