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Skeletal muscle metabolism in growin...

Manso Filho, Helio Cordeiro.

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Skeletal muscle metabolism in growing foals and transition mares.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Skeletal muscle metabolism in growing foals and transition mares./
作者:	Manso Filho, Helio Cordeiro.
面頁冊數:	177 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2360.
Contained By:	Dissertation Abstracts International66-05B.
標題:	Agriculture, Animal Culture and Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3176203
ISBN:	9780542156694

Skeletal muscle metabolism in growing foals and transition mares.
Manso Filho, Helio Cordeiro.

Skeletal muscle metabolism in growing foals and transition mares. - 177 p.

Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2360.

Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick, 2005.

Postnatal period is a critical period for the future of the equine athlete. During this period, the metabolism of foals and mares has closer relationship between their skeletal muscle and amino acid metabolism. The aims of the present study were to test the hypothesis that growth in foals and during transition period in mares would produce changes in glucose transporter 4 (Glut-4) and glutamine synthetase (GS) protein expression in skeletal muscle. Also it was expected that adaptations in skeletal muscles would be associated with changes in muscle and plasma metabolites, serum hormones, and body composition in both groups. Results from these studies showed that significant changes occurred in body composition in growing foals, with a large increase in fat-free mass during neonatal period (p < 0.05). In transition mares fat-free mass decreased during lactation (p < 0.05). All metabolites and hormones analyzed showed significant changes during growth and transition period. Also, this study demonstrated that leptin was present in newborn foals at birth, before milk ingestion. Glut-4 protein expression in skeletal muscle was higher at birth then decreases during development of the suckling foal (p < 0.05). Exercise training did not alter Glut-4 protein expression in weanling foals, adult mares, and old mares. GS expression was lower at birth in foals but in few days occurred a greater increase in its expression (p < 0.05). Correlation between GS expression and muscle free glutamine concentration was negative (R = -0.40, p < 0.05) in growing foals. GS expression changed during lactation in mares (p < 0.05), and GS expression in equine placenta was higher at pregnant horn when compared with non-pregnant horn and skeletal muscle. Free glutamine concentration changed rapidly in both muscle and plasma pools in foals (p < 0.05). Differently, free glutamine concentration changed in plasma (p < 0.05) and in milk (p < 0.05), but not in skeletal muscle (p > 0.05) in transition mares. Overall, these results showed major physiological adaptations in skeletal muscle with significant changes in Glut-4 and GS expression in growing foals and transition mares. These changes in Glut-4 and GS expression provide a metabolic safety net for both groups of horse, growing foals and transition mares, with profound impacts on the future of the equine athlete.

ISBN: 9780542156694Subjects--Topical Terms:

1017857
Agriculture, Animal Culture and Nutrition.

Skeletal muscle metabolism in growing foals and transition mares.
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