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The role of FIP200 in the coordinate...

Gan, Boyi.

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The role of FIP200 in the coordinated control of cell growth and cell survival during embryonic development.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The role of FIP200 in the coordinated control of cell growth and cell survival during embryonic development./
作者:	Gan, Boyi.
面頁冊數:	177 p.
附註:	Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0039.
Contained By:	Dissertation Abstracts International67-01B.
標題:	Biology, Cell. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3205167
ISBN:	9780542533365

The role of FIP200 in the coordinated control of cell growth and cell survival during embryonic development.
Gan, Boyi.

The role of FIP200 in the coordinated control of cell growth and cell survival during embryonic development. - 177 p.

Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0039.

Thesis (Ph.D.)--Cornell University, 2006.

During metazoan development, the increase of cell size and number and thus the growth of an organ or organism are coordinately regulated by three important biological processes, namely cell growth, cell proliferation and cell survival/death. Perturbation of these processes could lead to malformation or embryonic death, as well as a variety of diseases in adult life, such as cancer. In contrast to our understanding of the molecular mechanisms that regulate these cellular processes, less is known about the mechanisms how cell growth and cell survival/death are coordinately regulated during the development of organism. This thesis identifies FIP200 (focal adhesion kinase [FAK] family interacting protein of 200 kD) as an important regulator of TSC and TNFalpha signaling pathways and shows that FIP200 plays a role in the coordinated control of both cell growth and cell survival during mouse embryonic development.

ISBN: 9780542533365Subjects--Topical Terms:

1017686
Biology, Cell.

The role of FIP200 in the coordinated control of cell growth and cell survival during embryonic development.
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245 1 4 $a The role of FIP200 in the coordinated control of cell growth and cell survival during embryonic development.
300 $a 177 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0039.
500 $a Adviser: Jun-Lin Guan.
502 $a Thesis (Ph.D.)--Cornell University, 2006.
520 $a During metazoan development, the increase of cell size and number and thus the growth of an organ or organism are coordinately regulated by three important biological processes, namely cell growth, cell proliferation and cell survival/death. Perturbation of these processes could lead to malformation or embryonic death, as well as a variety of diseases in adult life, such as cancer. In contrast to our understanding of the molecular mechanisms that regulate these cellular processes, less is known about the mechanisms how cell growth and cell survival/death are coordinately regulated during the development of organism. This thesis identifies FIP200 (focal adhesion kinase [FAK] family interacting protein of 200 kD) as an important regulator of TSC and TNFalpha signaling pathways and shows that FIP200 plays a role in the coordinated control of both cell growth and cell survival during mouse embryonic development.
520 $a FIP200 is a recently characterized putative tumor suppressor protein that has been shown to regulate diverse cellular functions such as cell proliferation, cell spreading and migration in vitro. In an attempt to investigate the molecular mechanisms by which FIP200 regulates other intracellular signaling pathways and cellular functions, we identified a novel interaction between FIP200 and the TSC1-TSC2 complex through binding to TSC1. Further investigation has indicated that FIP200 functions to up-regulate S6 kinase phosphorylation and cell size by its inhibition of the TSC1-TSC2 complex function and that FIP200 plays a role nutrient stimulation-induced S6 kinase phosphorylation (Chapter 2). Together, these results suggest a novel cellular function of FIP200 in the regulation of cell growth by interaction with the TSC1-TSC2 complex.
520 $a To further study the function of FIP200 in vivo, we generated FIP200 kockout (KO) mouse and found that inactivation of FIP200 gene resulted in mid/late-gestational embryonic lethality caused by heart failure and liver lesions. Analysis of the FIP200 KO embryos showed decreased S6K activation and cell size, suggesting a role for FIP200 in the regulation of TSC-S6K signaling in vivo. Furthermore, significant apoptosis was observed in the liver and heart of FIP200 KO embryos and FIP200 KO MEFs showed increased apoptosis and decreased JNK signaling in response to TNFalpha stimulation, suggesting a role for FIP200 in the regulation of TNFalpha-JNK signaling pathways in cell survival/apoptosis (Chapter 3). Together, these findings reveal the important function of FIP200 in the coordinated regulation of cell growth and cell survival during embryonic development.
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