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Mechanical fragility calibration of ...

Gu, Lei.

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Mechanical fragility calibration of red blood cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Mechanical fragility calibration of red blood cells./
Author:	Gu, Lei.
Description:	225 p.
Notes:	Source: Dissertation Abstracts International, Volume: 63-12, Section: B, page: 5959.
Contained By:	Dissertation Abstracts International63-12B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3074000
ISBN:	9780493937212

Mechanical fragility calibration of red blood cells.
Gu, Lei.

Mechanical fragility calibration of red blood cells. - 225 p.

Source: Dissertation Abstracts International, Volume: 63-12, Section: B, page: 5959.

Thesis (D.Eng.)--Cleveland State University, 2002.

Mechanical fragility of RBCs is an important issue with respect to the testing of blood pumps. Unfortunately, no standardized test for RBC mechanical fragility is currently documented to be effective. Though many test devices have been proposed for the study of mechanical fragility of RBCs, no one has ever shown that the results have any relevance to a blood pump. Therefore, the objective of this study was to determine if one or more test devices could be validated as calibrators to compare or evaluate hemolysis levels of blood pumps.

ISBN: 9780493937212Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Mechanical fragility calibration of red blood cells.
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020 $a 9780493937212
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100 1 $a Gu, Lei. $3 1910719
245 1 0 $a Mechanical fragility calibration of red blood cells.
300 $a 225 p.
500 $a Source: Dissertation Abstracts International, Volume: 63-12, Section: B, page: 5959.
500 $a Adviser: William A. Smith.
502 $a Thesis (D.Eng.)--Cleveland State University, 2002.
520 $a Mechanical fragility of RBCs is an important issue with respect to the testing of blood pumps. Unfortunately, no standardized test for RBC mechanical fragility is currently documented to be effective. Though many test devices have been proposed for the study of mechanical fragility of RBCs, no one has ever shown that the results have any relevance to a blood pump. Therefore, the objective of this study was to determine if one or more test devices could be validated as calibrators to compare or evaluate hemolysis levels of blood pumps.
520 $a We tested a Biopump simultaneously with five test devices using five batches of bovine blood and letting the blood age. Then we simulated the shear stress and energy dissipation rate in the five test devices.
520 $a The results showed that the stainless steel bead test, when characterized by an index of hemolysis, was the best calibrator of mechanical fragility of RBCs, with respect to the blood pump. It was also shown that the product of average energy dissipation rate and exposure time t or the product of shear stress and t1/2 correlated with the actual hemolysis caused by each test device. These simulations may be used in the future to predict the hemolysis.
590 $a School code: 0466.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biophysics, General. $3 1019105
690 $a 0541
690 $a 0786
710 2 0 $a Cleveland State University. $3 1020754
773 0 $t Dissertation Abstracts International $g 63-12B.
790 1 0 $a Smith, William A., $e advisor
790 $a 0466
791 $a D.Eng.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3074000