語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
The pharmacogenetics of paclitaxel a...
~
Fukunaga, Anna Kim.
FindBook
Google Book
Amazon
博客來
The pharmacogenetics of paclitaxel and gemcitabine.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
The pharmacogenetics of paclitaxel and gemcitabine./
作者:
Fukunaga, Anna Kim.
面頁冊數:
143 p.
附註:
Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4174.
Contained By:
Dissertation Abstracts International66-08B.
標題:
Health Sciences, Pharmacy. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3185759
ISBN:
9780542276392
The pharmacogenetics of paclitaxel and gemcitabine.
Fukunaga, Anna Kim.
The pharmacogenetics of paclitaxel and gemcitabine.
- 143 p.
Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4174.
Thesis (Ph.D.)--Purdue University, 2005.
Paclitaxel binds to beta tubulin, causing stabilization of polymerized microtubules resulting in cell cycle arrest and the inhibition of mitosis. Recently, low-dose paclitaxel has demonstrated anti-angiogenic activity. A phase I trial was designed to assess the safety of escalating paclitaxel in combination with alpha interferon. Pharmacokinetic parameters of paclitaxel alone and in combination with interferon are determined using ADAPT software. Paclitaxel exhibits variable pharmacokinetics and toxicity. Polymorphisms in the paclitaxel pharmacologic pathway may help explain this interindividual variability. Seventeen subjects in this phase I trial were genotyped using PCR and pyrosequencing techniques. Nine polymorphisms in ABCB1, CYP2C8 and NR1I2 were genotyped to determine if genotype influences Cmax, AUC and clearance. Paclitaxel pharmacokinetic parameters are not affected by co-administration with interferon. Subjects who are homozygous for the variant allele, T, for ABCB1 3435 demonstrates lower paclitaxel clearance than subjects homozygous for the wild type, C, allele.
ISBN: 9780542276392Subjects--Topical Terms:
1017737
Health Sciences, Pharmacy.
The pharmacogenetics of paclitaxel and gemcitabine.
LDR
:03422nmm 2200289 4500
001
1820837
005
20061103104856.5
008
130610s2005 eng d
020
$a
9780542276392
035
$a
(UnM)AAI3185759
035
$a
AAI3185759
040
$a
UnM
$c
UnM
100
1
$a
Fukunaga, Anna Kim.
$3
1910041
245
1 4
$a
The pharmacogenetics of paclitaxel and gemcitabine.
300
$a
143 p.
500
$a
Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4174.
500
$a
Major Professors: Daryl J. Murry; Michael Kays.
502
$a
Thesis (Ph.D.)--Purdue University, 2005.
520
$a
Paclitaxel binds to beta tubulin, causing stabilization of polymerized microtubules resulting in cell cycle arrest and the inhibition of mitosis. Recently, low-dose paclitaxel has demonstrated anti-angiogenic activity. A phase I trial was designed to assess the safety of escalating paclitaxel in combination with alpha interferon. Pharmacokinetic parameters of paclitaxel alone and in combination with interferon are determined using ADAPT software. Paclitaxel exhibits variable pharmacokinetics and toxicity. Polymorphisms in the paclitaxel pharmacologic pathway may help explain this interindividual variability. Seventeen subjects in this phase I trial were genotyped using PCR and pyrosequencing techniques. Nine polymorphisms in ABCB1, CYP2C8 and NR1I2 were genotyped to determine if genotype influences Cmax, AUC and clearance. Paclitaxel pharmacokinetic parameters are not affected by co-administration with interferon. Subjects who are homozygous for the variant allele, T, for ABCB1 3435 demonstrates lower paclitaxel clearance than subjects homozygous for the wild type, C, allele.
520
$a
Gemcitabine is a nucleoside analog that is primarily used in the treatment of pancreatic cancer and is also approved for use in NSCLC and breast cancer. Gemcitabine competes with endogenous dCTP, for incorporation during DNA synthesis. Gemcitabine demonstrates interindividual variability. Because gemcitabine has a complex pharmacologic pathway, it is not likely that a single polymorphism in a single gene can explain the variability in gemcitabine metabolism and toxicity. Polymorphisms throughout the pathway were identified and genotyped in three populations, European, African and Asian. Haplotypes of DCK and CDA, were constructed in the European, Asian and African population. Polymorphisms in the 5'FR of DCK and CDA were analyzed in 52 paired (tumor and normal) colorectal cancer samples to determine if they were significant predictors of mRNA expression. dFdC pathway SNP analysis revealed significant differences in variant allele frequencies among the three populations. Three haplotypes for DCK captured ∼90% of the genomic structure in the three populations evaluated consequently, DCK haplotypes may be a useful tool in association studies. Because of the lack of linkage disequilibrium in CDA, individual polymorphisms may offer more information on the genotype-phenotype relationship. Lastly, in the 52 colorectal cancer samples, DCK and CDA 5 'FR genotype does not affect mRNA expression.
590
$a
School code: 0183.
650
4
$a
Health Sciences, Pharmacy.
$3
1017737
690
$a
0572
710
2 0
$a
Purdue University.
$3
1017663
773
0
$t
Dissertation Abstracts International
$g
66-08B.
790
1 0
$a
Murry, Daryl J.,
$e
advisor
790
1 0
$a
Kays, Michael,
$e
advisor
790
$a
0183
791
$a
Ph.D.
792
$a
2005
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3185759
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9211700
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入