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Poly(amidoamine) (PAMAM) dendrimers ...

Devarakonda, Bharathi.

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Poly(amidoamine) (PAMAM) dendrimers as solubility and permeation enhancers.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Poly(amidoamine) (PAMAM) dendrimers as solubility and permeation enhancers./
作者:	Devarakonda, Bharathi.
面頁冊數:	220 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2079.
Contained By:	Dissertation Abstracts International66-04B.
標題:	Chemistry, Pharmaceutical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3170725
ISBN:	9780542068737

Poly(amidoamine) (PAMAM) dendrimers as solubility and permeation enhancers.
Devarakonda, Bharathi.

Poly(amidoamine) (PAMAM) dendrimers as solubility and permeation enhancers. - 220 p.

Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2079.

Thesis (Ph.D.)--University of Louisiana at Monroe, 2005.

The aim of this study was to synthesize and investigate the solubilization and permeation enhancing potential of PAMAM dendrimers with different generation sizes and functional groups. Dendrimers are highly branched and reactive three-dimensional macromolecules with all bonds emanating from a central core. Since their introduction in the mid 1980's, this novel class of polymeric materials has attracted considerable attention because of their unique structures and properties. Compared with traditional linear polymers, dendrimers have more accurately controlled structures, with a globular shape, a single molecular weight, and a large number of controllable peripheral surface functionalities.

ISBN: 9780542068737Subjects--Topical Terms:

550957
Chemistry, Pharmaceutical.

Poly(amidoamine) (PAMAM) dendrimers as solubility and permeation enhancers.
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245 1 0 $a Poly(amidoamine) (PAMAM) dendrimers as solubility and permeation enhancers.
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500 $a Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2079.
500 $a Major Professor: Melgardt M. de Villiers.
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520 $a The aim of this study was to synthesize and investigate the solubilization and permeation enhancing potential of PAMAM dendrimers with different generation sizes and functional groups. Dendrimers are highly branched and reactive three-dimensional macromolecules with all bonds emanating from a central core. Since their introduction in the mid 1980's, this novel class of polymeric materials has attracted considerable attention because of their unique structures and properties. Compared with traditional linear polymers, dendrimers have more accurately controlled structures, with a globular shape, a single molecular weight, and a large number of controllable peripheral surface functionalities.
520 $a Many families of dendrimers with various core molecules and building monomers have been synthesized and are commercially available now. But, the family of dendrimers most investigated for drug delivery is the PAMAM dendrimers. PAMAM dendrimers are biocompatible, non-immunogenic, water-soluble and possess terminal-modifiable amine functional groups for binding various targeting or guest molecules. The internal cavities of PAMAM dendrimers can host metals or guest molecules because of the unique functional architecture, which contains tertiary amines and amide linkages.
520 $a In the present study, the solubilization potential of PAMAM dendrimers was investigated using four practically water insoluble drugs (niclosamide, nifedipine, furosemide, and paclitaxel) as model drugs. Further, the solubilization potential of the dendrimers was compared with that of traditionally used supramolecular compounds, i.e. cyclodextrins. The permeation enhancement potential of the dendrimers was investigated after oral and topical administration of drug-dendrimer complexes, and on the permeability of paclitaxel across cancerous cells.
520 $a Results showed that PAMAM dendrimers have the potential to significantly increase the aqueous solubility of these model drugs. In addition, significantly higher solubility of the drugs was observed in the presence of the dendrimers than in the presence of cyclodextrins. Also in vitro permeation studies using dendrimers as permeation/penetration enhancers showed that PAMAM dendrimers have the potential to significantly increase the permeability of drugs for oral and topical delivery and cellular entry of drugs across cancerous cells. Significant differences in the solubilization and permeation enhancement properties were observed between the PAMAM dendrimers with different generation sizes and surface functional groups (amine terminated versus ester terminated dendrimers).
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