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Response, regulation, and repair by ...

Harrast, Sonja Douglas.

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Response, regulation, and repair by distinct subsets of murine intestinal intraepithelial lymphocytes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Response, regulation, and repair by distinct subsets of murine intestinal intraepithelial lymphocytes./
作者:	Harrast, Sonja Douglas.
面頁冊數:	167 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0643.
Contained By:	Dissertation Abstracts International65-02B.
標題:	Health Sciences, Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3123330
ISBN:	9780496706419

Response, regulation, and repair by distinct subsets of murine intestinal intraepithelial lymphocytes.
Harrast, Sonja Douglas.

Response, regulation, and repair by distinct subsets of murine intestinal intraepithelial lymphocytes. - 167 p.

Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0643.

Thesis (Ph.D.)--Emory University, 2004.

The small intestine is filled with countless foreign proteins including food antigens, symbiotic bacteria, and harmful pathogens. The survival of the organism depends on enterocyte absorption of nutrients with the simultaneous prevention of systemic access to local flora and infectious microorganisms. Within the epithelial barrier lies a diverse collection of immune cells called the intestinal intraepithelial lymphocytes (IELs), the vast majority of which are T cells. Intraepithelial T cells are distinct from those found in lymph nodes and spleen due to their considerable number of gammadelta T cell receptor (TCR) expressing cells and unique assembly of co-receptors, particularly the intestine specific receptor CD8alphaalpha. A variety of antigens and effector functions have been proposed for phenotypically distinct subsets of IELs. We studied the behavior of several groups separately under various conditions in the murine small intestine in an attempt to contribute to the understanding of these cells. This body of work provides an analysis of IELs through surface marker characterizations, examination of TCRalphabeta IEL function in TCRgammadelta deficient mice, and IEL population studies in IL-12 deficient and food restricted wild-type mice.

ISBN: 9780496706419Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Response, regulation, and repair by distinct subsets of murine intestinal intraepithelial lymphocytes.
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520 $a The small intestine is filled with countless foreign proteins including food antigens, symbiotic bacteria, and harmful pathogens. The survival of the organism depends on enterocyte absorption of nutrients with the simultaneous prevention of systemic access to local flora and infectious microorganisms. Within the epithelial barrier lies a diverse collection of immune cells called the intestinal intraepithelial lymphocytes (IELs), the vast majority of which are T cells. Intraepithelial T cells are distinct from those found in lymph nodes and spleen due to their considerable number of gammadelta T cell receptor (TCR) expressing cells and unique assembly of co-receptors, particularly the intestine specific receptor CD8alphaalpha. A variety of antigens and effector functions have been proposed for phenotypically distinct subsets of IELs. We studied the behavior of several groups separately under various conditions in the murine small intestine in an attempt to contribute to the understanding of these cells. This body of work provides an analysis of IELs through surface marker characterizations, examination of TCRalphabeta IEL function in TCRgammadelta deficient mice, and IEL population studies in IL-12 deficient and food restricted wild-type mice.
520 $a Characterization of IELs from wild-type and infected mice revealed an activated phenotype characterized by CD69 and CD44 expression on nearly all cells regardless of subset or infection. Prior studies in TCRgammadelta deficient mice have provided increasing evidence of an immunoregulatory function for gammadelta T cells. In keeping with this theory, our results in these mice revealed a significant increase in the production of the pro-inflammatory cytokine IFN-gamma by TCRalphabeta IELs thereby supporting the hypothesis that gammadelta T cells down-regulate inflammation in the intestine under normal conditions. In addition to their anti-inflammatory role, we showed that TCRgammadelta IELs produce IFN-gamma in an IL-12 dependent manner. Analysis of IEL populations in IL-12 deficient mice revealed a striking absence of CD4+CD8+ expressing cells reflecting a role for IL-12 in IEL differentiation or maturation. Finally, acute fasting induced significant increases in TCRgammadelta IELs possibly in response to epithelial damage in accordance with their involvement in epithelial repair. These studies revealed the complexity of IELs as both pro-inflammatory and regulatory cells.
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