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The role of intestinal permeability ...

Gundlapalli, Sushama.

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The role of intestinal permeability in non-alcoholic steatohepatitis.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The role of intestinal permeability in non-alcoholic steatohepatitis./
作者:	Gundlapalli, Sushama.
面頁冊數:	32 p.
附註:	Source: Masters Abstracts International, Volume: 43-06, page: 2183.
Contained By:	Masters Abstracts International43-06.
標題:	Health Sciences, Medicine and Surgery. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1425978
ISBN:	0542051079

The role of intestinal permeability in non-alcoholic steatohepatitis.
Gundlapalli, Sushama.

The role of intestinal permeability in non-alcoholic steatohepatitis. - 32 p.

Source: Masters Abstracts International, Volume: 43-06, page: 2183.

Thesis (M.S.)--Rush University, 2005.

Purpose. One of the proposed second hit mechanisms in the pathophysiology of Nonalcoholic steatohepatitis (HASH) is oxidative stress triggered by endotoxin. We aim to determine whether patients with NASH have intestinal hyperpermeability.

ISBN: 0542051079Subjects--Topical Terms:

1017756
Health Sciences, Medicine and Surgery.

The role of intestinal permeability in non-alcoholic steatohepatitis.
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100 1 $a Gundlapalli, Sushama. $3 1908575
245 1 4 $a The role of intestinal permeability in non-alcoholic steatohepatitis.
300 $a 32 p.
500 $a Source: Masters Abstracts International, Volume: 43-06, page: 2183.
500 $a Director: Ali Keshavarzian.
502 $a Thesis (M.S.)--Rush University, 2005.
520 $a Purpose. One of the proposed second hit mechanisms in the pathophysiology of Nonalcoholic steatohepatitis (HASH) is oxidative stress triggered by endotoxin. We aim to determine whether patients with NASH have intestinal hyperpermeability.
520 $a Methods. Steatosis (n = 6) and NASH (n = 10) were diagnosed by liver biopsy. Intestinal permeability was measured using urinary excretion of poorly absorbed sugars. The permeability test was repeated after aspirin challenge. Small bowel permeability was defined by the Lactulose/Mannitol (L/M) ratio and whole gut permeability was defined by sucralose excretion.
520 $a Results. Whole gut permeability was similar between groups at baseline; however, patients with NASH had a significant increase in whole gut permeability with aspirin challenge, compared to both controls, and steatosis. Patients with Steatosis had no increased susceptibility to leakiness with aspirin.
520 $a Discussion. Our data indicate that patients with NASH are susceptible to colonic leakiness. This susceptibility should result in increased endotoxemia and oxidative stress in these patients.
590 $a School code: 0821.
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
650 4 $a Health Sciences, Pathology. $3 1017854
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792 $a 2005
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