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Neuroprotective effects of peroxisom...

Aoun, Paul.

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Neuroprotective effects of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands against oxidative stress.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Neuroprotective effects of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands against oxidative stress./
Author:	Aoun, Paul.
Description:	254 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2358.
Contained By:	Dissertation Abstracts International65-05B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3134632
ISBN:	0496818589

Neuroprotective effects of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands against oxidative stress.
Aoun, Paul.

Neuroprotective effects of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands against oxidative stress. - 254 p.

Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2358.

Thesis (Ph.D.)--University of North Texas Health Science Center at Fort Worth, 2004.

Diabetes mellitus is a significant public health problem in the United States and the world resulting in substantial morbidity and mortality. Diabetes complications, i.e., neuropathy, are common and almost triple the annual cost of managing diabetes. In our studies, we investigated the role that insulin sensitizers currently used for the treatment of diabetes, the PPAR-gamma ligands, might play in protecting neurons against oxidative stresses. We showed that two PPAR-gamma ligands, 15deoxy-PGJ2 and troglitazone, protected, in a dose-dependent manner, HT-22 mouse hippocampal and RGC-5 retinal ganglion cell lines against various oxidative insults. Further, we demonstrated that neuroprotection by 15deoxy-PGJ2 and troglitazone was independent of the PPAR-gamma receptor. Our findings brought to light an important role of PPAR-gamma ligands in preventing neuronal complications from diabetes. Moreover, the studies reported herein provide valuable insights into the development of novel therapeutic compounds that improve insulin sensitivity while preventing neurological, and possibly other, complications of diabetes.

ISBN: 0496818589Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Neuroprotective effects of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands against oxidative stress.
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100 1 $a Aoun, Paul. $3 1908443
245 1 0 $a Neuroprotective effects of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands against oxidative stress.
300 $a 254 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2358.
500 $a Adviser: James W. Simpkins.
502 $a Thesis (Ph.D.)--University of North Texas Health Science Center at Fort Worth, 2004.
520 $a Diabetes mellitus is a significant public health problem in the United States and the world resulting in substantial morbidity and mortality. Diabetes complications, i.e., neuropathy, are common and almost triple the annual cost of managing diabetes. In our studies, we investigated the role that insulin sensitizers currently used for the treatment of diabetes, the PPAR-gamma ligands, might play in protecting neurons against oxidative stresses. We showed that two PPAR-gamma ligands, 15deoxy-PGJ2 and troglitazone, protected, in a dose-dependent manner, HT-22 mouse hippocampal and RGC-5 retinal ganglion cell lines against various oxidative insults. Further, we demonstrated that neuroprotection by 15deoxy-PGJ2 and troglitazone was independent of the PPAR-gamma receptor. Our findings brought to light an important role of PPAR-gamma ligands in preventing neuronal complications from diabetes. Moreover, the studies reported herein provide valuable insights into the development of novel therapeutic compounds that improve insulin sensitivity while preventing neurological, and possibly other, complications of diabetes.
590 $a School code: 1250.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
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690 $a 0564
710 2 0 $a University of North Texas Health Science Center at Fort Worth. $3 1021741
773 0 $t Dissertation Abstracts International $g 65-05B.
790 1 0 $a Simpkins, James W., $e advisor
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791 $a Ph.D.
792 $a 2004
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