東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

An evaluation of the effects of the ...

Vogt, Janet Anne.

Linked to FindBook

Google Book

Amazon

博客來

An evaluation of the effects of the colonic fermentation of L-rhamnose and lactulose on biosynthesis and serum concentrations of cholesterol and triacylglycerol-fatty acids and serum short-chain fatty acids in humans.

Record Type:	Electronic resources : Monograph/item
Title/Author:	An evaluation of the effects of the colonic fermentation of L-rhamnose and lactulose on biosynthesis and serum concentrations of cholesterol and triacylglycerol-fatty acids and serum short-chain fatty acids in humans./
Author:	Vogt, Janet Anne.
Description:	218 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3070.
Contained By:	Dissertation Abstracts International66-06B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR02869
ISBN:	0494028696

An evaluation of the effects of the colonic fermentation of L-rhamnose and lactulose on biosynthesis and serum concentrations of cholesterol and triacylglycerol-fatty acids and serum short-chain fatty acids in humans.
Vogt, Janet Anne.

An evaluation of the effects of the colonic fermentation of L-rhamnose and lactulose on biosynthesis and serum concentrations of cholesterol and triacylglycerol-fatty acids and serum short-chain fatty acids in humans. - 218 p.

Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3070.

Thesis (Ph.D.)--University of Toronto (Canada), 2005.

It has been suggested that the hypocholesterolemic effect of soluble dietary fiber may be mediated by differences in the proportions of acetic and propionic acids produced during its colonic fermentation. To test this, 3 crossover studies were conducted in which the unabsorbable sugars lactulose and L-rhamnose were fed to human subjects. These sugars were chosen because previous studies had shown that in vitro fermentation of lactulose produces mainly acetate while L-rhamnose produces mainly propionate.

ISBN: 0494028696Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

An evaluation of the effects of the colonic fermentation of L-rhamnose and lactulose on biosynthesis and serum concentrations of cholesterol and triacylglycerol-fatty acids and serum short-chain fatty acids in humans.
LDR:03315nmm 2200301 4500 001 1818173
005 20060829131828.5
008 130610s2005 eng d
020 $a 0494028696
035 $a (UnM)AAINR02869
035 $a AAINR02869
040 $a UnM $c UnM
100 1 $a Vogt, Janet Anne. $3 1907514
245 1 3 $a An evaluation of the effects of the colonic fermentation of L-rhamnose and lactulose on biosynthesis and serum concentrations of cholesterol and triacylglycerol-fatty acids and serum short-chain fatty acids in humans.
300 $a 218 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3070.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2005.
520 $a It has been suggested that the hypocholesterolemic effect of soluble dietary fiber may be mediated by differences in the proportions of acetic and propionic acids produced during its colonic fermentation. To test this, 3 crossover studies were conducted in which the unabsorbable sugars lactulose and L-rhamnose were fed to human subjects. These sugars were chosen because previous studies had shown that in vitro fermentation of lactulose produces mainly acetate while L-rhamnose produces mainly propionate.
520 $a Experiment 1. Twenty-two healthy subjects ingested 25 g of lactulose, L-rhamnose, or D-glucose in divided doses over a 12-hour period and serum short-chain fatty acids and breath gases were measured. Compared to D-glucose, L-rhamnose increased serum propionate, while lactulose increased serum acetate, the ratio of acetate to propionate in serum, and breath hydrogen.
520 $a Experiment 2. Eleven healthy males ingested 25 g/d of the 3 sugars over three 28-day study periods. Short-chain fatty acid concentrations were measured in serum, urine, and feces. L-rhamnose increased serum propionate, but the increase in serum acetate on lactulose was not significant. However, lactulose increased the ratio of acetate to propionate in both serum and urine.
520 $a Experiment 3. Eighteen healthy males ingested 25 g/d of the 3 sugars over three 28-day study periods. Fasting serum lipid concentrations and biosynthesis of triacylglycerol-fatty acids and cholesterol were measured. Fasting serum cholesterol was unchanged but serum triacylglycerol, expressed as a percentage change from baseline, was decreased by both L-rhamnose and lactulose, compared to D-glucose, which raised it. Synthesis of triacylglycerol-fatty acids on day 28 was also significantly lower on L-rhamnose and lactulose than on D-glucose.
520 $a In conclusion, the data presented in this dissertation do not support the hypothesis that soluble fiber's hypocholesterolemic effect is mediated by differences in the colonic production of acetate and propionate. However, the ability of both lactulose and L-rhamnose to reverse the hypertriacylglycerolemic effect of an equal weight of D-glucose deserves further study, especially given the importance of elevated triacylglycerol concentrations as an independent risk factor for cardiovascular disease.
590 $a School code: 0779.
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Biology, Animal Physiology. $3 1017835
690 $a 0570
690 $a 0433
710 2 0 $a University of Toronto (Canada). $3 1017674
773 0 $t Dissertation Abstracts International $g 66-06B.
790 $a 0779
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR02869