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Circadian modulation of brain areas ...

Novak, Colleen Margaret.

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Circadian modulation of brain areas that control the sleep-wake cycle in diurnal and nocturnal rodents.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Circadian modulation of brain areas that control the sleep-wake cycle in diurnal and nocturnal rodents./
作者:	Novak, Colleen Margaret.
面頁冊數:	177 p.
附註:	Source: Dissertation Abstracts International, Volume: 60-10, Section: B, page: 5021.
Contained By:	Dissertation Abstracts International60-10B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9948149
ISBN:	0599502290

Circadian modulation of brain areas that control the sleep-wake cycle in diurnal and nocturnal rodents.
Novak, Colleen Margaret.

Circadian modulation of brain areas that control the sleep-wake cycle in diurnal and nocturnal rodents. - 177 p.

Source: Dissertation Abstracts International, Volume: 60-10, Section: B, page: 5021.

Thesis (Ph.D.)--Michigan State University, 1999.

The sleep wake cycle follows a circadian pattern that depends upon a signal from the suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, regardless of whether the animal is active during the day (diurnal) or night (nocturnal). The work presented in this dissertation investigated how the SCN differentially modulates brain areas known to be important in the control of sleep or wakefulness in nocturnal and diurnal animals, using the immediate-early gene product Fos as an index of neuronal activity. The daily patterns of Fos expression in these brain regions were monitored in the nocturnal murid rodent, Rattus norvegicus, and in a diurnal murid rodent, Arvicanthis niloticus.

ISBN: 0599502290Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Circadian modulation of brain areas that control the sleep-wake cycle in diurnal and nocturnal rodents.
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100 1 $a Novak, Colleen Margaret. $3 1907182
245 1 0 $a Circadian modulation of brain areas that control the sleep-wake cycle in diurnal and nocturnal rodents.
300 $a 177 p.
500 $a Source: Dissertation Abstracts International, Volume: 60-10, Section: B, page: 5021.
500 $a Adviser: Antonio A. Nunez.
502 $a Thesis (Ph.D.)--Michigan State University, 1999.
520 $a The sleep wake cycle follows a circadian pattern that depends upon a signal from the suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, regardless of whether the animal is active during the day (diurnal) or night (nocturnal). The work presented in this dissertation investigated how the SCN differentially modulates brain areas known to be important in the control of sleep or wakefulness in nocturnal and diurnal animals, using the immediate-early gene product Fos as an index of neuronal activity. The daily patterns of Fos expression in these brain regions were monitored in the nocturnal murid rodent, Rattus norvegicus, and in a diurnal murid rodent, Arvicanthis niloticus.
520 $a In both the diurnal and nocturnal species, Fos expression in the ventrolateral preoptic area (VLPO) showed a significant daily rhythm that peaked during the inactive phase of the cycle, when sleep episodes are frequent. The VLPO was found to receive only a minor direct input from the SCN. Therefore, the circadian regulation of VLPO neural activity is likely to involve multisynaptic pathways or the effects of humoral outputs of SCN neurons.
520 $a Rhythms of Fos activity were also detected in the paraventricular thalamic nucleus (PVT) and in the centromedial thalamic nucleus (CMT) in the rat. Further, Fos expression in the PVT and CMT was negatively correlated with Fos expression in the VLPO. In the PVT of both species, significant peaks of neural activity were associated with times of peak behavioral activity. In both species, the PVT receives projections from the SCN, some of which are vasopressinergic. Therefore, circadian regulation of PVT neural activity is likely to be mediated by direct inputs from the SCN. In A. niloticus, but not in the rat, neuronal activity in the histaminergic cells of the ventral tuberomammillary nucleus was associated with behavioral activity and wakefulness at dawn and dusk. This species difference suggests that the support of wakefulness may involve different neural systems in nocturnal and diurnal mammals.
520 $a In summary, the interactions between the SCN and regions of the brain that control vigilance and sleep differ between species and may be responsible for the emergence of a diurnal or nocturnal pattern of behavior.
590 $a School code: 0128.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Psychology, Physiological. $3 1017869
650 4 $a Psychology, Psychobiology. $3 1017821
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690 $a 0989
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710 2 0 $a Michigan State University. $3 676168
773 0 $t Dissertation Abstracts International $g 60-10B.
790 1 0 $a Nunez, Antonio A., $e advisor
790 $a 0128
791 $a Ph.D.
792 $a 1999
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