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Atrial fibrillation: Physiologic cha...

McRury, Ian Douglas.

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Atrial fibrillation: Physiologic characteristics and therapeutic approaches.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Atrial fibrillation: Physiologic characteristics and therapeutic approaches./
作者:	McRury, Ian Douglas.
面頁冊數:	189 p.
附註:	Source: Dissertation Abstracts International, Volume: 59-02, Section: B, page: 0747.
Contained By:	Dissertation Abstracts International59-02B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9824246
ISBN:	059176458X

Atrial fibrillation: Physiologic characteristics and therapeutic approaches.
McRury, Ian Douglas.

Atrial fibrillation: Physiologic characteristics and therapeutic approaches. - 189 p.

Source: Dissertation Abstracts International, Volume: 59-02, Section: B, page: 0747.

Thesis (Ph.D.)--University of Virginia, 1998.

Introduction. New treatments have been proposed as a cure for atrial fibrillation (AF): implantable cardioverters and a transcatheter maze procedure, which sections the atria using radiofrequency (RF) energy.

ISBN: 059176458XSubjects--Topical Terms:

1017684
Engineering, Biomedical.

Atrial fibrillation: Physiologic characteristics and therapeutic approaches.
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245 1 0 $a Atrial fibrillation: Physiologic characteristics and therapeutic approaches.
300 $a 189 p.
500 $a Source: Dissertation Abstracts International, Volume: 59-02, Section: B, page: 0747.
500 $a Adviser: David E. Haines.
502 $a Thesis (Ph.D.)--University of Virginia, 1998.
520 $a Introduction. New treatments have been proposed as a cure for atrial fibrillation (AF): implantable cardioverters and a transcatheter maze procedure, which sections the atria using radiofrequency (RF) energy.
520 $a Specific aims. (I) Arrhythmogenisis - To see if long linear lesions in the atria of normal dogs cause or reduce arrhythmias. (II) RF Ablation Monitoring - To use a new monitoring scheme for long electrodes to reduce complications such as: char, high impedance, and lesion discontinuity. (III) Ablation of AF - Use new techniques to ablate AF in a canine model of chronic AF. (IV) Lesion Gaps - To investigate the conduction properties of gaps in linear lesions. (V) To measure electrophysiologic indices of the state of the atrial tissue and relate it to the energy required for cardioversion.
520 $a Results. (I) Three right atrial RF ablation lines were created in normal dogs. Electrophysiologic testing was performed initially and after each of the lesions was completed. The formation of a complete set of linear, right atrial lesions reduced the ability to induce and sustain AF in normal hearts. There was no acute increase in the prevalence of tachycardias after the creation of an entire lesion set, but there was an acute increase in prevalence after an incomplete lesion set, and at a follow-up study 1-4 weeks later. (II) Finite element analysis and in vivo testing of two electrode temperature sensing configurations showed a significant disparity between the temperatures achieved at an electrode edge versus the midpoint. Monitoring of temperatures from the edges of the electrodes significantly reduced the occurrances of adherrent char, and impedance rises during temperature feedback power controlled radiofrequency ablation. (III) RF ablation of AF was performed successfully in dogs with chronic AF. There were many complications including fatalities from embolized thrombus, and sinus node disorder requiring pacemaker implantation. (IV) Discontinous lesions with gaps of 1-5 mm were able to block atrial conduction from one side of the lesion to the other. The conduction during AF was predicted by that during sinus pacing. (V) Internal atrial defibrillation thresholds decrease as atrial refractory period and spatial organization increase.
590 $a School code: 0246.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
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773 0 $t Dissertation Abstracts International $g 59-02B.
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790 $a 0246
791 $a Ph.D.
792 $a 1998
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9824246