語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Influence of post-injury ultrasound ...
~
McBrier, Nicole M.
FindBook
Google Book
Amazon
博客來
Influence of post-injury ultrasound treatments on skeletal muscle regeneration.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Influence of post-injury ultrasound treatments on skeletal muscle regeneration./
作者:
McBrier, Nicole M.
面頁冊數:
120 p.
附註:
Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3099.
Contained By:
Dissertation Abstracts International66-06B.
標題:
Health Sciences, Rehabilitation and Therapy. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3179678
ISBN:
0542197189
Influence of post-injury ultrasound treatments on skeletal muscle regeneration.
McBrier, Nicole M.
Influence of post-injury ultrasound treatments on skeletal muscle regeneration.
- 120 p.
Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3099.
Thesis (Ph.D.)--The Ohio State University, 2005.
Non-thermal ultrasound (US) is commonly used in an attempt to improve tissue repair and regeneration, although the efficacy of this practice is not firmly established. US is normally described in terms of duty cycle and spatial averaged intensity (SAI; W/cm2). The combination of these two, spatial averaged temporal averaged intensity (SATA), provides an indication of total energy delivered per unit of time. There is an untested suggestion that using non-thermal US treatments with an equivalent SATA, but that use different combination of duty cycle and SAI might produce different results. Following skeletal muscle injury there is a relatively defined series of events that take place during repair. Previous research has investigated only a few dependent variables at discreet points in time. To better identify the influence of ultrasound on skeletal muscle regeneration, it is vital to examine multiple protocols as well as multiple markers of regeneration at various time points. Therefore, the purposes of these studies were to examine the influence of non-thermal ultrasound markers on skeletal muscle regeneration and to compare 4 different combinations of duty cycle and SAI representing two common SATA intensities. Design and setting. Multifactorial designs comparing treatment, duty cycle, SATA, and time were used. A bilateral contusion injury to the gastrocnemius via a drop mass technique was performed. US administration commenced 24-hr post-injury and was delivered 5 minutes daily on 4 consecutive days. Rats received the US treatment on their left hindlimb, and the contralateral right hindlimb served as a non-US control. Subjects. Male Wistar rats were used in this study and the protocol was ILACUC approved. Measurements. Dependent variables included muscle mass, fiber cross-sectional area, centrally localized nuclei, embryonic myosin heavy chain, MGF (muscle specific IGF-1), M-cadherin, and MyoD. Data were analyzed using a factorial MANOVA. Results. US increased muscle mass more than no treatment (P < 0.0001) and increases in muscle mass were found with the continuous US treatment compared to the pulsed duty cycle treatment at the same SATA (P = 0.019). The interaction of treatment and SATA on fiber cross sectional area (P = 0.021) and centrally located nuclei (P = 0.016) is statistically significant. In the second experiment, ultrasound treatments also statistically significantly affected MGF levels compared to non-treated hind limb (P = 0.029). Ultrasound had no effect on muscle mass (P = 0.251). There was an effect observed for the day post-injury for MGF (P = 0.014) but not for mass (P = 0.290). Posthoc testing revealed that the MGF value on 1 day post-injury was statistically greater than the values observed for days 3 and 4 after injury. Conclusions. The specific non-thermal ultrasound treatments we studied had beneficial effects on skeletal muscle regeneration following blunt trauma. When comparing US treatments providing identical energy delivery, a continuous duty cycle has a greater influence on skeletal muscle regeneration following blunt trauma than does a pulsed duty cycle.
ISBN: 0542197189Subjects--Topical Terms:
1017926
Health Sciences, Rehabilitation and Therapy.
Influence of post-injury ultrasound treatments on skeletal muscle regeneration.
LDR
:04058nmm 2200289 4500
001
1817074
005
20060816133917.5
008
130610s2005 eng d
020
$a
0542197189
035
$a
(UnM)AAI3179678
035
$a
AAI3179678
040
$a
UnM
$c
UnM
100
1
$a
McBrier, Nicole M.
$3
1906437
245
1 0
$a
Influence of post-injury ultrasound treatments on skeletal muscle regeneration.
300
$a
120 p.
500
$a
Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3099.
500
$a
Adviser: Steven T. Devor.
502
$a
Thesis (Ph.D.)--The Ohio State University, 2005.
520
$a
Non-thermal ultrasound (US) is commonly used in an attempt to improve tissue repair and regeneration, although the efficacy of this practice is not firmly established. US is normally described in terms of duty cycle and spatial averaged intensity (SAI; W/cm2). The combination of these two, spatial averaged temporal averaged intensity (SATA), provides an indication of total energy delivered per unit of time. There is an untested suggestion that using non-thermal US treatments with an equivalent SATA, but that use different combination of duty cycle and SAI might produce different results. Following skeletal muscle injury there is a relatively defined series of events that take place during repair. Previous research has investigated only a few dependent variables at discreet points in time. To better identify the influence of ultrasound on skeletal muscle regeneration, it is vital to examine multiple protocols as well as multiple markers of regeneration at various time points. Therefore, the purposes of these studies were to examine the influence of non-thermal ultrasound markers on skeletal muscle regeneration and to compare 4 different combinations of duty cycle and SAI representing two common SATA intensities. Design and setting. Multifactorial designs comparing treatment, duty cycle, SATA, and time were used. A bilateral contusion injury to the gastrocnemius via a drop mass technique was performed. US administration commenced 24-hr post-injury and was delivered 5 minutes daily on 4 consecutive days. Rats received the US treatment on their left hindlimb, and the contralateral right hindlimb served as a non-US control. Subjects. Male Wistar rats were used in this study and the protocol was ILACUC approved. Measurements. Dependent variables included muscle mass, fiber cross-sectional area, centrally localized nuclei, embryonic myosin heavy chain, MGF (muscle specific IGF-1), M-cadherin, and MyoD. Data were analyzed using a factorial MANOVA. Results. US increased muscle mass more than no treatment (P < 0.0001) and increases in muscle mass were found with the continuous US treatment compared to the pulsed duty cycle treatment at the same SATA (P = 0.019). The interaction of treatment and SATA on fiber cross sectional area (P = 0.021) and centrally located nuclei (P = 0.016) is statistically significant. In the second experiment, ultrasound treatments also statistically significantly affected MGF levels compared to non-treated hind limb (P = 0.029). Ultrasound had no effect on muscle mass (P = 0.251). There was an effect observed for the day post-injury for MGF (P = 0.014) but not for mass (P = 0.290). Posthoc testing revealed that the MGF value on 1 day post-injury was statistically greater than the values observed for days 3 and 4 after injury. Conclusions. The specific non-thermal ultrasound treatments we studied had beneficial effects on skeletal muscle regeneration following blunt trauma. When comparing US treatments providing identical energy delivery, a continuous duty cycle has a greater influence on skeletal muscle regeneration following blunt trauma than does a pulsed duty cycle.
590
$a
School code: 0168.
650
4
$a
Health Sciences, Rehabilitation and Therapy.
$3
1017926
650
4
$a
Health Sciences, Medicine and Surgery.
$3
1017756
650
4
$a
Engineering, Biomedical.
$3
1017684
690
$a
0382
690
$a
0564
690
$a
0541
710
2 0
$a
The Ohio State University.
$3
718944
773
0
$t
Dissertation Abstracts International
$g
66-06B.
790
1 0
$a
Devor, Steven T.,
$e
advisor
790
$a
0168
791
$a
Ph.D.
792
$a
2005
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3179678
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9207937
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入