語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Computational studies on evolution a...
~
Alkan, Can.
FindBook
Google Book
Amazon
博客來
Computational studies on evolution and functionality of genomic repeats.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Computational studies on evolution and functionality of genomic repeats./
作者:
Alkan, Can.
面頁冊數:
92 p.
附註:
Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2668.
Contained By:
Dissertation Abstracts International66-05B.
標題:
Computer Science. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3176582
ISBN:
0542157543
Computational studies on evolution and functionality of genomic repeats.
Alkan, Can.
Computational studies on evolution and functionality of genomic repeats.
- 92 p.
Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2668.
Thesis (Ph.D.)--Case Western Reserve University, 2005.
Human DNA consists of a large number of repeat sequences. The repeat sequences can be in the form of tandem repeats and interspersed repeats and cover more than 60% of the human genome sequence. Segmental repeats are a result of duplication events that have occurred during the evolution of human genome. This dissertation presents an algorithmic and computational study of the repeat sequences with emphasis on the identification of the location and order of duplication events as well as the identification of the responsible cellular mechanisms. A complementary goal of this work is to study the effect of the repeat sequences to gene regulation. Thus it provides a comprehensive study of the evolution and function of repeat sequences in the human genome.
ISBN: 0542157543Subjects--Topical Terms:
626642
Computer Science.
Computational studies on evolution and functionality of genomic repeats.
LDR
:03537nmm 2200325 4500
001
1816406
005
20060717095835.5
008
130610s2005 eng d
020
$a
0542157543
035
$a
(UnM)AAI3176582
035
$a
AAI3176582
040
$a
UnM
$c
UnM
100
1
$a
Alkan, Can.
$3
1905791
245
1 0
$a
Computational studies on evolution and functionality of genomic repeats.
300
$a
92 p.
500
$a
Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2668.
500
$a
Adviser: S. Cenk Sahinalp.
502
$a
Thesis (Ph.D.)--Case Western Reserve University, 2005.
520
$a
Human DNA consists of a large number of repeat sequences. The repeat sequences can be in the form of tandem repeats and interspersed repeats and cover more than 60% of the human genome sequence. Segmental repeats are a result of duplication events that have occurred during the evolution of human genome. This dissertation presents an algorithmic and computational study of the repeat sequences with emphasis on the identification of the location and order of duplication events as well as the identification of the responsible cellular mechanisms. A complementary goal of this work is to study the effect of the repeat sequences to gene regulation. Thus it provides a comprehensive study of the evolution and function of repeat sequences in the human genome.
520
$a
The primary example of tandem repeat sequences in the human genome are the centromeric alpha-satellite DNA that consists of arbitrary monomer pairs of size approximately 171bp. Although it is possible that alpha-satellite sequences developed as a result of subsequent unequal crossovers only, no formal computational framework had been developed to verify this possibility. This thesis includes such a framework and reports on experiments which imply that pericentromeric alpha-satellite segments are evolutionarily distinct from the higher-order repeat segments.
520
$a
Certain repeat sequences are not only interesting for evolutionary studies but also have essential functional properties. Recent studies demonstrate the existence of special antisense RNAs used in post-transcriptional gene regulation through binding with duplicate target sequences in the mRNA. These RNAs are known to be synthesized naturally to control gene expression in C. elegans, Drosophila and other organisms, or regulate plasmid copy numbers in E. coli; they have also been artificially constructed to knock-out genes of interest in humans and other organisms in order to find out their functions as well as for other purposes.
520
$a
Several computational methods can be used to predict the secondary structure of a single RNA molecule, but no such algorithm exists for reliably predicting the joint secondary structure of two interacting RNA molecules, or measuring the stability of such a joint structure. This dissertation presents a combinatorial approach for solving the RNA-RNA interaction prediction problem between an antisense RNA and its target mRNA. Three main models for joint structure prediction are introduced, and the proposed methods are applied to discover targets for any given antisense RNA in whole genomic and plasmid sequences.
590
$a
School code: 0042.
650
4
$a
Computer Science.
$3
626642
650
4
$a
Biology, Genetics.
$3
1017730
650
4
$a
Biology, Biostatistics.
$3
1018416
690
$a
0984
690
$a
0369
690
$a
0308
710
2 0
$a
Case Western Reserve University.
$3
1017714
773
0
$t
Dissertation Abstracts International
$g
66-05B.
790
1 0
$a
Sahinalp, S. Cenk,
$e
advisor
790
$a
0042
791
$a
Ph.D.
792
$a
2005
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3176582
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9207269
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入