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The fate and function of tumor-speci...

Tan, Gladys Gek-Yen.

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The fate and function of tumor-specific T cells during immune reconstitution.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The fate and function of tumor-specific T cells during immune reconstitution./
作者:	Tan, Gladys Gek-Yen.
面頁冊數:	193 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6281.
Contained By:	Dissertation Abstracts International65-12B.
標題:	Health Sciences, Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3155692
ISBN:	0496164988

The fate and function of tumor-specific T cells during immune reconstitution.
Tan, Gladys Gek-Yen.

The fate and function of tumor-specific T cells during immune reconstitution. - 193 p.

Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6281.

Thesis (Ph.D.)--The Johns Hopkins University, 2005.

During the course of tumor progression, tumor-specific CD4+ T cells are rendered tolerant. Here we have reported that with the application of bone marrow transplantation, it is possible to reverse this state of tolerance. T cells taken from tumor bearing donors (documented to be hyporesponsive to tumor antigen) undergo a rapid transition to effector cells when transplanted into irradiated, syngeneic tumor-bearing recipients, leading to significant clonal expansion and gamma-IFN production. Furthermore, the capacity of these tolerant T cells to respond to vaccination is restored. This endogenous activation is antigen-driven, and requires capture and presentation of tumor antigens by CD40 competent host APCs, and translates into a high degree of anti-tumor efficacy. IL-7R-mediated signaling appears to be crucial in promoting this endogenous activation of the tumor-specific T cells and is certainly involved in the reversal of tumor-specific T cell tolerance.

ISBN: 0496164988Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

The fate and function of tumor-specific T cells during immune reconstitution.
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