東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Function analysis of viral glycoprot...

Jiang, Haiqing.

FindBook

Google Book

Amazon

博客來

Function analysis of viral glycoprotein in viral infection.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Function analysis of viral glycoprotein in viral infection./
作者:	Jiang, Haiqing.
面頁冊數:	98 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-11, Section: B, page: 5535.
Contained By:	Dissertation Abstracts International65-11B.
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3154423
ISBN:	0496149199

Function analysis of viral glycoprotein in viral infection.
Jiang, Haiqing.

Function analysis of viral glycoprotein in viral infection. - 98 p.

Source: Dissertation Abstracts International, Volume: 65-11, Section: B, page: 5535.

Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2005.

Ebola viruses are enveloped, nonsegmented, negative-stranded RNA viruses. Together with Marburg viruses, they are classified in the order of Mononegavirales and the family of Filoviridae. Ebola GP2 protein, which is a type I viral fusion protein, mediates virus-host membrane fusion. The role of the charged residues in the function of Ebola GP2 was evaluated by a HIV-based pseudotyping system. We found that several charged residues are important for GP2 function. In contrast a similar analysis of the charged residues of HIV-1 gp41 showed different effect from Ebola GP2, especially in C-helix. These results suggest that the charged residues of Ebola GP2 may participate in the formation of fusion-active GP2 conformation or play a role in GP2 intermediate status in fusion process. We also demonstrate that Ebola GP2 played an active role in virus release by characterizing a gain-of-function Ebola GP2 mutant. We showed the enhanced infectivity probably resulted from the newly acquired GP2 association with raft-like lipid microdomains during virus budding.

ISBN: 0496149199Subjects--Topical Terms:

1017734
Biology, Microbiology.

Function analysis of viral glycoprotein in viral infection.
LDR:01977nmm 2200289 4500 001 1816120
005 20060717151404.5
008 130610s2005 eng d
020 $a 0496149199
035 $a (UnM)AAI3154423
035 $a AAI3154423
040 $a UnM $c UnM
100 1 $a Jiang, Haiqing. $3 1905515
245 1 0 $a Function analysis of viral glycoprotein in viral infection.
300 $a 98 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-11, Section: B, page: 5535.
500 $a Chair: Lijun Rong.
502 $a Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2005.
520 $a Ebola viruses are enveloped, nonsegmented, negative-stranded RNA viruses. Together with Marburg viruses, they are classified in the order of Mononegavirales and the family of Filoviridae. Ebola GP2 protein, which is a type I viral fusion protein, mediates virus-host membrane fusion. The role of the charged residues in the function of Ebola GP2 was evaluated by a HIV-based pseudotyping system. We found that several charged residues are important for GP2 function. In contrast a similar analysis of the charged residues of HIV-1 gp41 showed different effect from Ebola GP2, especially in C-helix. These results suggest that the charged residues of Ebola GP2 may participate in the formation of fusion-active GP2 conformation or play a role in GP2 intermediate status in fusion process. We also demonstrate that Ebola GP2 played an active role in virus release by characterizing a gain-of-function Ebola GP2 mutant. We showed the enhanced infectivity probably resulted from the newly acquired GP2 association with raft-like lipid microdomains during virus budding.
590 $a School code: 0806.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0410
690 $a 0307
690 $a 0982
710 2 0 $a University of Illinois at Chicago, Health Sciences Center. $3 1021703
773 0 $t Dissertation Abstracts International $g 65-11B.
790 1 0 $a Rong, Lijun, $e advisor
790 $a 0806
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3154423