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Analysis of H2-M3 restricted CD8+ T ...

Ploss, Alexander.

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Analysis of H2-M3 restricted CD8+ T cell responses following primary and secondary Listeria monocytogenes infection.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Analysis of H2-M3 restricted CD8+ T cell responses following primary and secondary Listeria monocytogenes infection./
作者:	Ploss, Alexander.
面頁冊數:	187 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-03, Section: B, page: 1383.
Contained By:	Dissertation Abstracts International66-03B.
標題:	Health Sciences, Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3169353
ISBN:	0542054604

Analysis of H2-M3 restricted CD8+ T cell responses following primary and secondary Listeria monocytogenes infection.
Ploss, Alexander.

Analysis of H2-M3 restricted CD8+ T cell responses following primary and secondary Listeria monocytogenes infection. - 187 p.

Source: Dissertation Abstracts International, Volume: 66-03, Section: B, page: 1383.

Thesis (Ph.D.)--Weill Medical College of Cornell University, 2005.

Murine infection with the Gram-positive intracellular bacterium Listeria monocytogenes (L.m.) activates CD8+ T cell responses that are restricted by MHC class IA molecules, such as H2-Kb or H2-Kd, and MHC class Ib molecules, such as H2-M3. MHC class la and Ib restricted CD8+ T cells both contribute to bacterial clearance but differ in several respects.

ISBN: 0542054604Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Analysis of H2-M3 restricted CD8+ T cell responses following primary and secondary Listeria monocytogenes infection.
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245 1 0 $a Analysis of H2-M3 restricted CD8+ T cell responses following primary and secondary Listeria monocytogenes infection.
300 $a 187 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-03, Section: B, page: 1383.
500 $a Adviser: Eric Pamer.
502 $a Thesis (Ph.D.)--Weill Medical College of Cornell University, 2005.
520 $a Murine infection with the Gram-positive intracellular bacterium Listeria monocytogenes (L.m.) activates CD8+ T cell responses that are restricted by MHC class IA molecules, such as H2-Kb or H2-Kd, and MHC class Ib molecules, such as H2-M3. MHC class la and Ib restricted CD8+ T cells both contribute to bacterial clearance but differ in several respects.
520 $a While MHC class IA restricted T cells are highly antigen-specific, H2-M3 restricted T cells are more promiscuous with respect to their peptide specificity. For example, CD8+ T cells specific for fMIGWII, a dominant H2-M3-restricted epitope derived from L.m., also recognize other bacterial peptides. fMIGWII deficient L. monocytogenes, generated in our laboratory, induced nearly normal sized populations of "fMIGWII-specific" T cells. Peptide cross-recognition is not unique to fMIGWII-specific T cells since CD8+ T cell responses specific for the sub-dominant fMIVTLF epitope were primed by infection with a L. monocytogenes strain lacking the non-redundant fMIVTLF sequence. While this degree of antigen receptor promiscuity is unusual for the adaptive immune system, it may be a more common feature of T cell responses restricted by non-polymorphic MHC class IA molecules.
520 $a H2-M3 and MHC class la restricted T cells also differ in their peripheral expansion kinetics in response to bacterial infection. Upon systemic re-infection MHC class la restricted memory CD8+ T cells expand vigorously. On the other hand, H2-M3 restricted memory CD8+ T cells undergo markedly diminished expansion. Adoptive transfer studies demonstrate that H2-M3-restricted T cells are out-competed by MHC class Ia-restricted CD8+ T cells during secondary but not during primary infection. This disparity is explained by rapid elimination of antigen-presenting cells during recall infection, preventing adequate re-stimulation of H2-M3 restricted memory CD8+ T cells. In vitro studies indicate that H2-M3 memory cells are less sensitive to antigen stimulation than MHC class IA restricted memory T cells. The rules of competition are distinct in different lymphoid tissues. Following subcutaneous re-infection, H2-M3-restricted memory T cells expand in lymph-nodes. We attribute this to prolonged H2-M3 antigen presentation due to diminished down-regulation of antigen-presenting cells (APCs) in the lymph-node. We propose that H2-M3 antigen presentation is prolonged due to the lack of immediate cytotoxicitiy of lymph-nodes resident central memory T cells. In aggregate, these studies have revealed differences between MHC class la and H2-M3 restricted T cells that bring to light important regulatory mechanisms that control the size of memory T cell populations.
590 $a School code: 0967.
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Biology, Microbiology. $3 1017734
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791 $a Ph.D.
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